组胺H2受体拮抗剂与大鼠脑内去甲肾上腺素能系统的相互作用。
An interaction of histamine H2-receptor antagonists with the noradrenergic system in rat brain.
作者信息
Nowak J Z, Pilc A, Maśliński C
出版信息
Eur J Pharmacol. 1978 Sep 1;51(1):71-5. doi: 10.1016/0014-2999(78)90063-8.
Intraventricular administration of 50 microgram of burimamide or 250 microgram of either metiamide or cimetidine decreased the NA concentration in rat hypothalamus by nearly 30%. Cimetidine did not significantly influence either DA or DOPAC levels in striatum. Cimetidine and metiamide significantly potentiated locomotor activity of tranylcypromine-treated rats and this effect was antagonized by phentolamine. It is concluded that the three histamine H2-receptor antagonists released NA in rat brain.
脑室内注射50微克的布立马胺或250微克的甲硫咪胺或西咪替丁可使大鼠下丘脑去甲肾上腺素（NA）浓度降低近30%。西咪替丁对纹状体中的多巴胺（DA）或3,4-二羟基苯乙酸（DOPAC）水平无显著影响。西咪替丁和甲硫咪胺可显著增强经反苯环丙胺处理大鼠的运动活性，且此效应可被酚妥拉明拮抗。得出的结论是，这三种组胺H2受体拮抗剂可使大鼠脑内释放去甲肾上腺素。
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