Lowe N J, David M
Division of Dermatology, UCLA School of Medicine.
Dermatol Clin. 1988 Oct;6(4):539-52.
Systemic administration of retinoids is frequently associated with mucocutaneous side effects, liver toxicity, and abnormalities of the serum lipid profile. Currently, the main factors limiting more common use of retinoids are their teratogenicity and chronic bone toxicity. Treatment with retinoids requires appropriate selection of patients, careful periodic monitoring of the clinical response, and appropriate laboratory tests. Careful therapeutic management is necessary in order to prevent or minimize side effects.
维甲酸的全身给药常常伴有皮肤黏膜副作用、肝毒性以及血清脂质谱异常。目前，限制维甲酸更广泛应用的主要因素是其致畸性和慢性骨毒性。使用维甲酸进行治疗需要适当选择患者，仔细定期监测临床反应，并进行适当的实验室检查。为了预防或尽量减少副作用，必须进行仔细的治疗管理。
