5-羟色胺受体亚型在大鼠脊髓反射通路中的功能意义。

Functional significance of subtypes of 5-HT receptors in the rat spinal reflex pathway.

Nagano N, Ono H, Fukuda H

Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.

Gen Pharmacol. 1988;19(6):789-93.

Abstract

The functional significance of subtypes of 5-hydroxytryptamine (5-HT) receptors was studied in the rat spinal reflex pathway. 2. Ketanserin had no effect on the mono- (MSR) or polysynaptic reflex (PSR) in spinal rats, but decreased the PSR in intact rats. 3. 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) decreased the MSR and increased the PSR in spinal rats. 4. Ketanserin antagonized the effects of 5-MeODMT without antagonizing the effects of 8-OH-DPAT. 5. Cinanserin had similar effects to those of ketanserin. 6. These results suggest that both 5-HT1A and 5-HT2 receptors mediate MSR inhibition and PSR augmentation in the spinal reflexes of spinal rats, and that the 5-HT2 receptor has a supraspinal tonic excitatory influence on the PSR in intact rats.

摘要

在大鼠脊髓反射通路中研究了5-羟色胺（5-HT）受体亚型的功能意义。2. 酮色林对脊髓大鼠的单突触反射（MSR）或多突触反射（PSR）无影响，但可降低完整大鼠的PSR。3. 8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）和5-甲氧基-N，N-二甲基色胺（5-MeODMT）可降低脊髓大鼠的MSR并增加PSR。4. 酮色林拮抗5-MeODMT的作用，但不拮抗8-OH-DPAT的作用。5. 辛那色林具有与酮色林相似的作用。6. 这些结果表明，5-HT1A和5-HT2受体均介导脊髓大鼠脊髓反射中MSR的抑制和PSR的增强，并且5-HT2受体对完整大鼠的PSR具有脊髓上的紧张性兴奋作用。