Hung Chien-Hui, Wang Chien-Neng, Cheng Huei-Hsuan, Liao Jiunn-Wang, Chen Yi-Ting, Chao Ya-Wen, Jiang Jia Liang, Lee Chen-Chen
Graduate Institute of Clinical Medical Science, College of Medicine, China Medicine University, Taichung, Taiwan.
Institute of Basic Medical Science, College of Medicine, China Medicine University, Taichung, Taiwan.
Planta Med. 2018 Oct;84(15):1110-1117. doi: 10.1055/a-0622-8242. Epub 2018 May 15.
Baicalin is the main flavonoid from the roots of an important medicinal plant, , which shows a variety biological activities. Psoriasis is a chronic immune-mediated inflammatory disease that affects the skin. The unmet need of psoriasis is that many patients do not respond adequately to available clinical treatment. In this study, we found that baicalin showed inhibited dermal inflammation in a murine model of psoriasis via topical application of imiquimod. After a 5-day topical imiquimod application, baicalin or the control vehicle cream was to applied to the lesions of BALB/c mice for a further 4 days. The erythema, scaling, and thickness of the epidermal layer significantly improved in the baicalin-treated mice. The levels of interleukin-17A, interleukin-22, interleukin-23, and tumor necrosis factor in the skin significantly decreased after baicalin treatment. Baicalin also inhibited imiquimod-induced interleukin-17A production in skin draining lymph node cells. The infiltration of T cells into the skin lesions induced by imiquimod was also suppressed after baicalin treatment. These results suggest that baicalin inhibited skin inflammation through the inhibition of the interleukin-17/interleukin-23 axis in a murine model of psoriasis.
黄芩苷是一种重要药用植物根部的主要黄酮类化合物，具有多种生物学活性。银屑病是一种影响皮肤的慢性免疫介导炎症性疾病。银屑病尚未满足的需求是许多患者对现有的临床治疗反应不佳。在本研究中，我们发现黄芩苷通过局部应用咪喹莫特在银屑病小鼠模型中表现出抑制皮肤炎症的作用。在局部应用咪喹莫特5天后，将黄芩苷或对照赋形剂乳膏进一步应用于BALB/c小鼠的皮损处4天。黄芩苷治疗的小鼠中，红斑、脱屑和表皮层厚度显著改善。黄芩苷治疗后，皮肤中白细胞介素-17A、白细胞介素-22、白细胞介素-23和肿瘤坏死因子水平显著降低。黄芩苷还抑制咪喹莫特诱导的皮肤引流淋巴结细胞中白细胞介素-17A的产生。黄芩苷治疗后，咪喹莫特诱导的皮肤病变中T细胞浸润也受到抑制。这些结果表明，在银屑病小鼠模型中，黄芩苷通过抑制白细胞介素-17/白细胞介素-23轴来抑制皮肤炎症。
