Rajkumar K, Sivakumar S, Arulraj R, Kaur Manpreet, Jasinski Jerry P, Manimekalai A, Thiruvalluvar A
Research and Development Centre, Bharathiar University, Coimbatore 641 046, Tamilnadu, India.
Department of Chemistry, Thiruvalluvar Arts and Science College, Kurinjipadi 607 302, Tamilnadu, India.
Acta Crystallogr E Crystallogr Commun. 2018 Mar 9;74(Pt 4):483-486. doi: 10.1107/S2056989018003766. eCollection 2018 Apr 1.
The syntheses and crystal structures of 3-(2-chloro-eth-yl)--2,-6-di-phenyl-piperidin-4-one, CHClNO, (I), and 3-(2-chloro-eth-yl)--2,-6-bis-(4-fluoro-phen-yl)piperidin-4-one, CHClFNO, (II), are described. The piperidone ring adopts a chair conformation in (I), whereas a slightly distorted chair conformation is formed in (II). The dihedral angle between the mean plane of the phenyl rings is 59.1 (1)° in (I) and 76.1 (1)° in (II). The crystal packing features weak inter-molecular N-H⋯O hydrogen bonds in each structure.
描述了3-(2-氯乙基)-2,6-二苯基哌啶-4-酮（CHClNO，(I)）和3-(2-氯乙基)-2,6-双(4-氟苯基)哌啶-4-酮（CHClFNO，(II)）的合成及晶体结构。哌啶酮环在(I)中呈椅式构象，而在(II)中形成稍扭曲的椅式构象。苯环平均平面之间的二面角在(I)中为59.1 (1)°，在(II)中为76.1 (1)°。每个结构的晶体堆积具有弱分子间N-H⋯O氢键。
