Siebels Henrike, Sohns Christian, Nürnberg Jan-Hendrik, Siebels Jürgen, Langes Klaus, Hebe Joachim
Department of Electrophysiology, Electrophysiology Center Bremen, Senator-Weßling-Str. 1, 28277, Bremen, Germany.
J Interv Card Electrophysiol. 2018 Nov;53(2):267-277. doi: 10.1007/s10840-018-0367-6. Epub 2018 May 15.
Radiofrequency current energy (RFC) ablation is still considered as the gold standard for atrioventricular nodal reentrant tachycardia (AVNRT). Success-rates for AVNRT ablation vary irrespective of the ablation technology and strategy. This study aimed to access safety, efficacy, and long-term outcome of RFC catheter ablation for the treatment of AVNRT in children and adolescents aged < 19 years with special focus on modulation versus ablation of the AV nodal slow pathway (SP).
A total number of 1143 patients (pts) < 19 years were referred for invasive electrophysiological testing due to paroxysmal supraventricular tachycardia (SVT).
Diagnosis of AVNRT was confirmed in 412 pts, and RFC-guided ablation was attempted in 386 pts (age 13.0 ± 3.5 years). No permanent complications were observed. RFC application resulted in SP-ablation in 171/386 (44.3%) and in SP modulation in 208/386 (53.9%) children, whereas attempts for RFC treatment failed in 7 pts. Follow-up was completed for 396/412 patients (96.1%). Within a mean follow-up period of 54.9 ± 39.7 months, in 51/379 pts (13.5%) AVNRT recurrence was observed. The median time until tachycardia recurrence was 19.5 months. No difference for AVNRT recurrence was found comparing SP ablation versus SP modulation (p > 0.05), whereas the recurrence rate was significantly higher in patients with non-inducible SVT and therefore empiric SP treatment as compared to patients with inducible AVNRT (p = 0.01).
RFC-guided ablation for AVNRT in children and adolescents is safe and leads to an acceptable long-term freedom from recurrences. SP modulation and SP ablation resulted in comparable acute and long-term success rates. Late AVNRT recurrences can occur even after years of freedom from tachycardia-related symptoms.
射频电流能量(RFC)消融仍被视为房室结折返性心动过速(AVNRT)的金标准。无论消融技术和策略如何,AVNRT消融的成功率各不相同。本研究旨在探讨RFC导管消融治疗19岁以下儿童和青少年AVNRT的安全性、有效性及长期预后,特别关注房室结慢径路(SP)的改良与消融。
共有1143例19岁以下患者因阵发性室上性心动过速(SVT)接受有创电生理检查。
412例患者确诊为AVNRT,其中386例(年龄13.0±3.5岁)尝试进行RFC引导下消融。未观察到永久性并发症。RFC应用导致171/386例(44.3%)儿童SP消融,208/386例(53.9%)儿童SP改良,7例RFC治疗尝试失败。412例患者中的396例(96.1%)完成随访。在平均54.9±39.7个月的随访期内,379例患者中有51例(13.5%)观察到AVNRT复发。心动过速复发的中位时间为19.5个月。比较SP消融与SP改良,AVNRT复发率无差异(p>0.05),而与可诱发AVNRT的患者相比,非诱发SVT并因此接受经验性SP治疗的患者复发率显著更高(p=0.01)。
RFC引导下消融治疗儿童和青少年AVNRT安全,长期复发率可接受。SP改良和SP消融的急性和长期成功率相当。即使在多年无心动过速相关症状后,AVNRT仍可能晚期复发。