Kulmyrzaeva Nazgul, Tatarunas Vacis, Skipskis Vilius, Smagulova Gaziza, Seitmaganbetova Nazgul, Veikutiene Audrone, Lesauskaite Vaiva
West Kazakhstan Marat Ospanov State Medical University, 030019 Aktobe city, Maresyev str., 68, Kazakhstan.
Institute of Cardiology of Lithuanian University of Health Sciences, Sukileliu 17, Kaunas, LT 50009, Lithuania.
Per Med. 2016 Sep;13(5):423-428. doi: 10.2217/pme-2016-0041. Epub 2016 Jun 6.
We present two clinical cases of acute and subacute coronary artery stent thrombosis in patients treated at the Department of Interventional Cardiology in Aktobe, Kazakhstan. Our results draw attention to the impact of CYP3A41B on the clinical effect of clopidogrel during dual antiplatelet therapy after PCI. The genotyping performed at the Laboratory of Molecular Cardiology of Institute of Cardiology of Lithuanian University of Health Sciences in Lithuania revealed that both patients were homozygous carriers of CYP3A41B*1B. They also were carriers of CYP2C19 loss-of-function *2 or *3 alleles (12 and 13, respectively).
