载小檗碱纳米载体的协同抗癌作用。
Synergistic anticancer effects of nanocarrier loaded with berberine and .
机构信息
Department of Preventive Dentistry, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin 150001, People's Republic of China.
Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin 150001, People's Republic of China.
出版信息
Biosci Rep. 2018 Jun 27;38(3). doi: 10.1042/BSR20180311. Print 2018 Jun 29.
We introduced polyethyleneimine (PEI)-cholesterol (PC) as a nanocarrier incorporating berberine (BER) and for the treatment of oral squamous cell carcinoma (OSCC). BER was stabilized by incorporating PC to form -PC. -PC was further electrostatically complexed with to yield PC for the co-delivery of BER and PC treatment dramatically decreased the level of invasion and migration of OSCC cells compared with single drug treatments. The present study suggested that PC could be a multifunctional nanocarrier for the co-delivery of anticancer drug BER and to significantly increase the anticancer therapeutic effects.
我们引入聚乙烯亚胺（PEI）-胆固醇（PC）作为一种纳米载体，将小檗碱（BER）和 整合在一起，用于治疗口腔鳞状细胞癌（OSCC）。通过将 PC 整合到 中来稳定 BER，形成 -PC。 -PC 进一步与 静电复合，生成 PC，用于共同递送 BER 和 。与单一药物治疗相比，PC 治疗显著降低了 OSCC 细胞的侵袭和迁移水平。本研究表明，PC 可以作为一种多功能纳米载体，共同递送抗癌药物 BER 和 ，显著提高抗癌治疗效果。
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