Amaratunga K R, Alvarez G G
Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON.
University of Ottawa, Department of Medicine, Division of Infectious Diseases, Ottawa, ON.
Can Commun Dis Rep. 2016 Mar 3;42(3):63-67. doi: 10.14745/ccdr.v42i03a03.
Although Canada has a low incidence of tuberculosis (TB), certain populations, including the foreign-born and Canadian-born Indigenous peoples, continue to be disproportionately represented among reported cases. The overall incidence rates of active TB in Canada have not significantly changed in the past decade and work still needs to be done to reach TB elimination goals set by the World Health Organization (WHO). In trying to achieve TB elimination in Canada, primary care clinicians, with the support of public health professionals and TB experts, can help by focusing on 1) targeted screening and treatment of latent TB infection (LTBI) and 2) timely diagnosis and referral of active TB disease. The following article focuses on some key primary care considerations to keep in mind in day-to-day patient care. To help conduct targeted screening and treatment for LTBI, several key populations, including immigrants from high TB burden countries, Indigenous peoples and several other at-risk groups, are outlined. Reactivation of LTBI plays a significant role in TB burden and is likely an area of major potential impact in achieving TB elimination. Advancement in LTBI treatment, including short course therapy, is also described. In addition, to help make a timely diagnosis of active TB, several key risk factors, including several co-morbidities which increase the risk of developing TB disease, can be considered. Being front-line in patient care, keeping in mind some of these key pearls may aid primary care providers to have potential impact on eliminating TB in Canada.
尽管加拿大的结核病发病率较低,但某些人群,包括外国出生者和加拿大出生的原住民,在报告病例中所占比例仍然过高。在过去十年中,加拿大活动性结核病的总体发病率没有显著变化,要实现世界卫生组织(WHO)设定的结核病消除目标,仍需努力。在加拿大努力实现结核病消除的过程中,初级保健临床医生在公共卫生专业人员和结核病专家的支持下,可以通过关注以下两点来提供帮助:1)对潜伏性结核感染(LTBI)进行有针对性的筛查和治疗;2)及时诊断和转诊活动性结核病。以下文章重点介绍了在日常患者护理中需要牢记的一些关键的初级保健注意事项。为了帮助对LTBI进行有针对性的筛查和治疗,文中概述了几个关键人群,包括来自结核病高负担国家的移民、原住民以及其他几个高危群体。LTBI的复发在结核病负担中起着重要作用,很可能是实现结核病消除的一个主要潜在影响领域。文中还介绍了LTBI治疗的进展,包括短程疗法。此外,为了帮助及时诊断活动性结核病,可以考虑几个关键的风险因素,包括一些增加患结核病风险的合并症。作为患者护理的一线人员,牢记其中一些关键要点可能有助于初级保健提供者对在加拿大消除结核病产生潜在影响。