Huang Lei, Boling Warren, Zhang John H
Department of Neurosurgery, School of Medicine, Loma Linda University, Loma Linda, CA, USA.
Department of Basic Sciences, Division of Physiology, School of Medicine, Loma Linda University, Loma Linda, CA, USA.
Med Gas Res. 2018 Apr 18;8(1):24-28. doi: 10.4103/2045-9912.229600. eCollection 2018 Jan-Mar.
Glioblastoma multiforme (GBM) is the most common type of malignant intracranial tumor in adults. Tumor tissue hypoxia, high mitotic rate, and rapid tumor spread account for its poor prognosis. Hyperbaric oxygen therapy (HBOT) may improve the sensitivity of radio-chemotherapy by increasing oxygen tension within the hypoxic regions of the neoplastic tissue. This review summarizes the research of HBOT applications within the context of experimental and clinical GBM. Limited clinical trials and preclinical studies suggest that radiotherapy immediately after HBOT enhances the effects of radiotherapy in some aspects. HBOT also is able to strengthen the anti-tumor effect of chemotherapy when applied together. Overall, HBOT is well tolerated in the GBM patients and does not significantly increase toxicity. However, HBOT applied by itself as curative strategy against GBM is controversial in preclinical studies and has not been evaluated rigorously in GBM patients. In addition to HBOT favorably managing the therapeutic resistance of GBM, future research needs to focus on the multimodal or cocktail approaches to treatment, as well as molecular strategies targeting GBM stem cells.
多形性胶质母细胞瘤（GBM）是成人中最常见的恶性颅内肿瘤类型。肿瘤组织缺氧、高有丝分裂率和肿瘤快速扩散导致其预后不良。高压氧治疗（HBOT）可通过增加肿瘤组织缺氧区域内的氧张力来提高放化疗的敏感性。本综述总结了在实验性和临床GBM背景下HBOT应用的研究。有限的临床试验和临床前研究表明，HBOT后立即进行放疗在某些方面增强了放疗效果。HBOT与化疗联合应用时也能够增强化疗的抗肿瘤作用。总体而言，GBM患者对HBOT耐受性良好，且不会显著增加毒性。然而，在临床前研究中，将HBOT作为针对GBM的治愈性策略存在争议，并且尚未在GBM患者中进行严格评估。除了HBOT能有效应对GBM的治疗耐药性外，未来的研究需要聚焦于多模式或联合治疗方法，以及针对GBM干细胞的分子策略。
