Ma X K, Liu J S
Department of Otorhinolaryngology, Zhangjiagang People's Hospital, Affiliated Hospital of Soochow University, Soochow, 215600, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 May;32(9):678-682. doi: 10.13201/j.issn.1001-1781.2018.09.009.
To investigate the expression of Nrf2 and Keap1 in nasopharyngeal carcinoma (NPC) and to analyze the relationship between the expression of Nrf2 and Keap1 and the clinicopathological features and prognosis of patients with nasopharyngeal carcinoma. A total of 108 patients with biopsy-proven nonkeratinizing squamous cell carcinoma-undifferentiated type with available biopsy specimens for tissue microarray (TMA) construction were selected. The relationship between Nrf2 and Keap1 protein expression and the prognosis of radiotherapy in patients with nasopharyngeal carcinoma was analyzed. The overall 5-year disease free survival (DFS) and overall survival(OS) rates were 57.4% and 70.2%, respectively. The 5-year DFS rate was 59.4% in the low nuclear Nrf2 expression group, and 53.8% in the high nuclear Nrf2 expression group. The 5-year DFS rate was 42.2% in the low cytoplasmic Keap1 expression group, and 68.2% in the high cytoplasmic Keap1 expression group. The 5-year OS rate was 70.8% in the low nuclear Nrf2 expression group, and 69.2% in the high nuclear Nrf2 expression group. The 5-year OS rate was 55.6% in the low cytoplasmic Keap1 expression group, and 80.9% in the high cytoplasmic Keap1 expression group.We found that nuclear Nrf2 or cytoplasmic Keap1 expression had no significant association with clinicopathological features. The high expression of cytoplasmic Keap1 had higher DFS and OS. Keap1 is an independent prognostic factor for DFS and OS in NPC patient.
探讨核因子E2相关因子2（Nrf2）和 Kelch样环氧氯丙烷相关蛋白1（Keap1）在鼻咽癌（NPC）中的表达情况，并分析Nrf2和Keap1的表达与鼻咽癌患者临床病理特征及预后的关系。选取108例经活检证实为非角化性鳞状细胞癌未分化型且有可用活检标本用于构建组织芯片（TMA）的患者。分析Nrf2和Keap1蛋白表达与鼻咽癌患者放疗预后的关系。总体5年无病生存率（DFS）和总生存率（OS）分别为57.4%和70.2%。低核Nrf2表达组5年DFS率为59.4%，高核Nrf2表达组为53.8%。低细胞质Keap1表达组5年DFS率为42.2%，高细胞质Keap1表达组为68.2%。低核Nrf2表达组5年OS率为70.8%，高核Nrf2表达组为69.2%。低细胞质Keap1表达组5年OS率为55.6%，高细胞质Keap1表达组为80.9%。我们发现核Nrf2或细胞质Keap1表达与临床病理特征无显著相关性。细胞质Keap1高表达具有较高的DFS和OS。Keap1是NPC患者DFS和OS的独立预后因素。
