Klen Jasna, Goričar Katja, Janež Andrej, Dolžan Vita
General Hospital Trbovlje, Rudarska cesta 9, 1420 Trbovlje, Slovenia.
Pharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.
Per Med. 2015 Jun;12(3):187-198. doi: 10.2217/pme.14.86.
AIM: To investigate if antioxidative genes' polymorphisms influence the risk for Type 2 diabetes (T2D) complications. MATERIALS & METHODS: In total, 181 T2D patients were genotyped for SOD2, CAT, GPX1, GSTP1, GSTM10, GSTT10, GCLC and GCLM. RESULTS: After adjustment for duration of T2D, CAT rs1001179 and GSTP1 rs1138272 showed strongest association with risk for end-stage kidney failure (p = 0.005 and p = 0.049, respectively). In patients without end-stage kidney failure CAT rs1001179 influenced urea levels (p = 0.003), while GSTP1 rs1695 and GSTP1 haplotypes influenced the risk of moderately increased albuminuria (p = 0.024 and p = 0.014, respectively). CONCLUSION: Common CAT and GSTP1 polymorphisms could be used to identify T2D patients at an increased risk for developing end-stage kidney failure.
目的：研究抗氧化基因多态性是否影响2型糖尿病（T2D）并发症的风险。 材料与方法：共对181例T2D患者进行了超氧化物歧化酶2（SOD2）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶1（GPX1）、谷胱甘肽S-转移酶P1（GSTP1）、谷胱甘肽S-转移酶M10（GSTM10）、谷胱甘肽S-转移酶T10（GSTT10）、谷氨酸半胱氨酸连接酶催化亚基（GCLC）和谷氨酸半胱氨酸连接酶调节亚基（GCLM）的基因分型。 结果：在对T2D病程进行校正后，CAT基因rs1001179位点和GSTP1基因rs1138272位点与终末期肾衰竭风险的相关性最强（p值分别为0.005和0.049）。在无终末期肾衰竭的患者中，CAT基因rsl001179位点影响尿素水平（p = 0.003），而GSTP1基因rs1695位点和GSTP1单倍型影响中度蛋白尿增加的风险（p值分别为0.024和0.014）。 结论：常见的CAT和GSTP1基因多态性可用于识别发生终末期肾衰竭风险增加的T2D患者。
Aging (Albany NY). 2018-2-4
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