谷胱甘肽S-转移酶M1、T1和P1基因多态性对2型糖尿病及糖尿病感觉运动性周围神经病变风险的影响

Influence of GSTM1, GSTT1, and GSTP1 Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Sensorimotor Peripheral Neuropathy Risk.

作者信息

Stoian Adina, Bănescu Claudia, Bălaşa Rodica Ioana, Moţăţăianu Anca, Stoian Mircea, Moldovan Valeriu G, Voidăzan Septimiu, Dobreanu Minodora

机构信息

Department of Pathophysiology, University of Medicine and Pharmacy, Gheorghe Marinescu 38, 540139 Tîrgu Mureş, Romania.

Department of Medical Genetics, University of Medicine and Pharmacy, Gheorghe Marinescu 38, 540139 Tîrgu Mureş, Romania.

出版信息

Dis Markers. 2015;2015:638693. doi: 10.1155/2015/638693. Epub 2015 Sep 8.

DOI:10.1155/2015/638693

PMID:26435566

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4578743/

Abstract

BACKGROUND AND AIMS

Diabetic neuropathy is a frequent complication of type 2 diabetes mellitus (T2DM). Genetic susceptibility and oxidative stress may play a role in the appearance of T2DM and diabetic neuropathy. We investigated the relation between polymorphism in genes related to oxidative stress such as GSTM1, GSTT1, and GSTP1 and the presence of T2DM and diabetic neuropathy (DN).

METHODS

Samples were collected from 84 patients with T2DM (42 patients with DN and 42 patients without DN) and 98 healthy controls and genotyped by using polymerase chain reaction and restriction fragment length polymorphism method.

RESULTS

GSTP1 Ile105Val polymorphism was associated with the risk of developing T2DM (p = 0.05) but not with the risk of developing DN in diabetic cases. GSTM1 and GSTT1 gene polymorphisms were associated with neither the risk of developing T2DM nor the risk of DN occurrence in diabetic patients. No association was observed between the patients with T2DM and DSPN (diabetic sensorimotor peripheral neuropathy) and T2DM without DSPN regarding investigated polymorphism.

CONCLUSION

Our data suggest that GSTP1 gene polymorphisms may contribute to the development of T2DM in Romanian population. GSTM1, GSTT1, and GSTP1 gene polymorphisms are not associated with susceptibility of developing diabetic neuropathy in T2DM patients.

摘要

背景与目的

糖尿病神经病变是2型糖尿病（T2DM）常见的并发症。遗传易感性和氧化应激可能在T2DM及糖尿病神经病变的发生中起作用。我们研究了与氧化应激相关的基因如谷胱甘肽S-转移酶M1（GSTM1）、谷胱甘肽S-转移酶T1（GSTT1）和谷胱甘肽S-转移酶P1（GSTP1）的多态性与T2DM及糖尿病神经病变（DN）发生之间的关系。

方法

收集84例T2DM患者（42例合并DN，42例未合并DN）及98例健康对照者的样本，采用聚合酶链反应和限制性片段长度多态性方法进行基因分型。

结果

GSTP1基因Ile105Val多态性与T2DM的发病风险相关（p = 0.05），但与糖尿病患者发生DN的风险无关。GSTM1和GSTT1基因多态性与糖尿病患者发生T2DM的风险及DN的发生风险均无关。在T2DM合并糖尿病性感觉运动性周围神经病（DSPN）患者与无DSPN的T2DM患者之间，未观察到所研究的多态性存在关联。

结论

我们的数据表明，GSTP1基因多态性可能在罗马尼亚人群T2DM的发生中起作用。GSTM1、GSTT1和GSTP1基因多态性与T2DM患者发生糖尿病神经病变的易感性无关。

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