Cancer Biology Research and Training Program, Department of Biological Sciences ,Alabama State University, Montgomery, AL 36104, USA.
Cancer Biology Research and Training, Department of Biological Sciences, Alabama State University, Montgomery, AL 36104.
Front Biosci (Landmark Ed). 2018 Jun 1;23(11):1987-2000. doi: 10.2741/4684.
In the United States, Prostate Cancer (PCa) is the leading cause of cancer-related mortality in men. PCa resulted in abnormal growth and function of prostate gland such as secretion of high level of gamma-seminoprotein (gama-SM)/Prostate-Specific Antigen (PSA) which could be detected in the blood. Beside gama-SM protein, the levels of heat shock proteins (Hsp70) were also observed significantly high. Therefore, gama-SM and Hsp70 are unique proteins with high potential for PCa therapeutics and diagnostics. High level of Hsp70 suppresses apoptosis, thus allowing PCa cells to exist; however, depletion of Hsp70 induces apoptosis in PCa cells. Gama-SM is the most prominent biomarker for PCa screening; however, its accuracy is still questionable. Thus, a more suitable streamline biomarker for PCa screening is urgently needed. Hsp70 and gama-SM proteins could be used as a revolutionary biomarker for PCa, and could help to identify possible therapeutic target(s). In this review article we will discuss the relationship between the Hsp70 and gama-SM proteins with PCa, their potential as a dual biomarker, and the possibility for both proteins being used as therapeutic targets.
在美国，前列腺癌（PCa）是男性癌症相关死亡的主要原因。PCa 导致前列腺异常生长和功能，例如高水平的γ-生殖细胞蛋白（gama-SM）/前列腺特异性抗原（PSA）的分泌，这些可以在血液中检测到。除了 gama-SM 蛋白外，热休克蛋白（Hsp70）的水平也观察到明显升高。因此，gama-SM 和 Hsp70 是具有高潜力的 PCa 治疗和诊断的独特蛋白质。Hsp70 水平高会抑制细胞凋亡，从而使 PCa 细胞得以存活；然而，Hsp70 的耗竭会诱导 PCa 细胞凋亡。gama-SM 是用于 PCa 筛查的最显著的生物标志物；然而，其准确性仍存在疑问。因此，迫切需要更合适的用于 PCa 筛查的流水线生物标志物。Hsp70 和 gama-SM 蛋白可用作 PCa 的革命性生物标志物，并有助于确定可能的治疗靶点。在这篇综述文章中，我们将讨论 Hsp70 和 gama-SM 蛋白与 PCa 的关系、它们作为双重生物标志物的潜力，以及这两种蛋白作为治疗靶点的可能性。
