Institut National de la Santé Et de la Recherche Médicale, U1016, Institut Cochin, 75014 Paris, France.
Centre National de la Recherche Scientifique, UMR8104, 75014 Paris, France.
Int J Mol Sci. 2018 May 17;19(5):1496. doi: 10.3390/ijms19051496.
Preeclampsia is a persistent hypertensive gestational disease characterized by high blood pressure and proteinuria, which presents from the second trimester of pregnancy. At the cellular level, preeclampsia has largely been associated with the release of free radicals by the placenta. Placenta-borne oxidative and nitrosative stresses are even sometimes considered as the major molecular determinants of the maternal disease. In this review, we present the recent literature evaluating free radical production in both normal and pathological placentas (including preeclampsia and other major pregnancy diseases), in humans and animal models. We then assess the putative effects of these free radicals on the placenta and maternal endothelium. This analysis was conducted with regard to recent papers and possible therapeutic avenues.
子痫前期是一种持续性高血压妊娠疾病,其特征为妊娠中期后出现高血压和蛋白尿。从细胞水平来看,子痫前期主要与胎盘释放自由基有关。胎盘来源的氧化和硝化应激甚至有时被认为是母体疾病的主要分子决定因素。在这篇综述中,我们评估了正常和病理性胎盘(包括子痫前期和其他主要妊娠疾病)中自由基产生的最新文献,包括人类和动物模型。然后,我们评估了这些自由基对胎盘和母体内皮的潜在影响。这项分析是针对最近的论文和可能的治疗途径进行的。