Comparison of Prooxidant Antioxidant Balance Between Neonates of Preeclamptic Mothers and Normal Pregnancies in Ghaem Hospital, Mashhad, From 2019 to 2022.

BACKGROUND AND AIMS

The current study has been carried out to compare PAB between neonates of preeclamptic mothers and mothers with normal pregnancies.

METHODS

This cross-sectional study has been carried out on 191 preterm neonates including 105 neonates with preeclamptic mothers (55%) and 86 neonates with non-preeclamptic mothers (45%) in Ghaem hospital, Mashhad, from 2019 to 2022. Sampling has been done by available sampling method. After delivery, PAB was measured from the umbilical cord of newborns with preeclamptic mothers and those with healthy mothers. Complete neonatal characteristics including first and fifth minute Apgar score, gestational age, birth weight, incident of respiratory distress syndrome (RDS), need for mechanical ventilation, condition at the time of discharge, and death was surveyed. Afterwards, using statistical methods, PAB amount in the umbilical cord of neonates with preeclamptic mothers and those with healthy mothers was compared.

RESULTS

In this study, mean amount of PAB in all neonates was 27.50 ± 36.70 HK. In neonates with preeclamptic mothers and those with healthy mothers, mean ± standard deviation (SD) of PAB was 36.89 ± 42.70 and 16.04 ± 23.21 HK, fifth minute Apgar score 8.1 ± 1.36 and 7.1 ± 1.46, and the birth weight 1328 ± 301.76 and 1443.61 ± 395.33, respectively. To identify neonates at risk of oxidative stress who were born to preeclamptic mothers (compared to healthy mothers' newborns), PAB > 11.2 HK had sensitivity of 88.2% and specificity of 75%.

CONCLUSION

PAB in neonates with preeclamptic mothers is disturbed, during preeclampsia its levels increase and also, this disturbance is associated with adverse neonatal outcomes such as low birth weight, increased incidence of RDS, and need for ventilation.