Edlich Richard, Hill Lisa G, Williams Freddie M
Legacy Verified Level I Shock Trauma Center Pediatrics and Adults, Legacy Emanual Hospital; and Plastic Surgery, Biomedical Engineering and Emergency Medicine, University of Virginia Health System, USA.
Plastic Surgery Research Program, University of Virginia Health System, Charlottesville, Virginia.
J Long Term Eff Med Implants. 2017;27(2-4):355-368. doi: 10.1615/JLongTermEffMedImplants.v27.i2-4.160.
Infection with human T-cell lymphotrophic virus-I (HTLV-I) is now a global epidemic, affecting 10 to 20 million people. This virus has been linked to life-threatening, incurable diseases, adult T-cell leukemia/lymphoma (ATLL), and HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), as well as several chronic illnesses, such as uveitis and dermatitis. The cumulative lifetime risk of developing these incurable diseases is approximately 5% in asymptomatic patients. For operating room personnel performing surgery among patients from high-risk groups, HTLV-I and its associated diseases are presenting an increasing challenge. This report describes its transmission, seroprevalence, treatment, and public health initiatives that must be instituted to prevent the spread of this retrovirus. Coinfection with HTLV-I and human immunodeficiency virus (HIV) has been shown to accelerate the progression of acquired immune deficiency syndrome (AIDS).
人类嗜T淋巴细胞病毒I型（HTLV-I）感染如今已成为一种全球流行病，感染人数达1000万至2000万。这种病毒与危及生命、无法治愈的疾病、成人T细胞白血病/淋巴瘤（ATLL）以及HTLV-I相关脊髓病/热带痉挛性截瘫（HAM/TSP）有关，还与几种慢性疾病如葡萄膜炎和皮炎有关。无症状患者一生中罹患这些无法治愈疾病的累积风险约为5%。对于在高危人群患者中进行手术的手术室工作人员而言，HTLV-I及其相关疾病带来的挑战日益增加。本报告描述了其传播、血清阳性率、治疗方法以及为防止这种逆转录病毒传播而必须采取的公共卫生举措。已证明HTLV-I与人类免疫缺陷病毒（HIV）合并感染会加速获得性免疫缺陷综合征（AIDS）的进展。
