调控信号转导通路的环肽：从原核生物到多细胞生物。
Cyclic Peptides that Govern Signal Transduction Pathways: From Prokaryotes to Multi-Cellular Organisms.
机构信息
Department of Chemistry, University of Nevada, Reno, NV 89557, United States.
出版信息
Curr Top Med Chem. 2018;18(7):625-644. doi: 10.2174/1568026618666180518090705.
Abstract
Cyclic peptide scaffolds are key components of signal transduction pathways in both prokaryotic and eukaryotic organisms since they act as chemical messengers that activate or inhibit specific cognate receptors. In prokaryotic organisms these peptides are utilized in non-essential pathways, such as quorum sensing, that are responsible for virulence and pathogenicity. In the more evolved eukaryotic systems, cyclic peptide hormones play a key role in the regulation of the overall function of multicellular organisms, mainly through the endocrine system. This review will highlight several prokaryote and eukaryote systems that use cyclic peptides as their primary signals and the potential associated with utilizing these scaffolds for the discovery of novel therapeutics for a wide range of diseases and illnesses.
摘要
环状肽支架是原核和真核生物信号转导途径的关键组成部分，因为它们作为化学信使，激活或抑制特定的同源受体。在原核生物中，这些肽用于非必需途径，如群体感应，这是负责毒力和致病性。在更进化的真核系统中，环状肽激素在调节多细胞生物体的整体功能中起着关键作用，主要通过内分泌系统。这篇综述将重点介绍几种使用环状肽作为主要信号的原核和真核系统，以及利用这些支架发现治疗各种疾病和病症的新型疗法的潜力。
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