采用单纯形格子设计优化口腔分散片和普通片剂：辅料与香蕉提取物的关系。

Optimization of orodispersible and conventional tablets using simplex lattice design: Relationship among excipients and banana extract.

机构信息

Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand.

Division of Pharmaceutical sciences, Faculty of Pharmacy, Thammasat University, Pathumthani, 12120, Thailand.

出版信息

Carbohydr Polym. 2018 Aug 1;193:89-98. doi: 10.1016/j.carbpol.2018.03.087. Epub 2018 Mar 27.

DOI:10.1016/j.carbpol.2018.03.087

PMID:29773401

Abstract

The objective of this study was focused on the optimization of the pharmaceutical excipients and banana extract in the preparation of orally disintegrating banana extract tablets (OD-BET) and conventional banana extract tablets (CO-BET) using a simplex lattice design. Various ratios of banana extract (BE), dibasic calcium phosphate (DCP) and microcrystalline cellulose (MCC) were used to prepare banana extract tablets (BET). The results indicated that the optimal OD-BET and CO-BET consisted of BE: DCP: MCC at 10.0, 88.8, 1.2, 10.0, 83.8: and 6.2, respectively. AFM demonstrated that the surface of BET with BE + MCC was smooth and compacted when compared to BET with BE + DCP + MCC and BE + DCP. FTIR and XRD showed a correlation in the results and indicated that no interaction of each ingredient occurred in the process of BET formulation. Therefore, the experimental design is potentially useful in formulated OD-BET and CO-BET by using only one design simultaneously.

摘要

本研究的目的是使用单纯形格子设计优化药用辅料和香蕉提取物，以制备口腔崩解香蕉提取物片（OD-BET）和常规香蕉提取物片（CO-BET）。使用不同比例的香蕉提取物（BE）、磷酸氢钙二水合物（DCP）和微晶纤维素（MCC）来制备香蕉提取物片（BET）。结果表明，OD-BET 和 CO-BET 的最佳配方分别为 BE:DCP:MCC 为 10.0、88.8、1.2 和 10.0、83.8:6.2。原子力显微镜（AFM）显示，与 BE+DCP+MCC 的 BET 相比，BE+MCC 的 BET 表面更光滑、更紧实。傅里叶变换红外光谱（FTIR）和 X 射线衍射（XRD）的结果表明，各成分之间没有相互作用。因此，通过同时使用一个设计，实验设计有可能用于 OD-BET 和 CO-BET 的配方。