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蛋白激酶 A 的激活：日下新事？

Protein kinase A activation: Something new under the sun?

机构信息

Howard Hughes Medical Institute, Department of Pharmacology, University of Washington, Seattle, WA.

Howard Hughes Medical Institute, Department of Pharmacology, University of Washington, Seattle, WA

出版信息

J Cell Biol. 2018 Jun 4;217(6):1895-1897. doi: 10.1083/jcb.201805011. Epub 2018 May 17.

DOI:10.1083/jcb.201805011
PMID:29773583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5987730/
Abstract

The role of autophosphorylation of the type II regulatory subunit in activation of protein kinase A (PKA) has been a longstanding question. In this issue, Isensee et al. (2018. https://doi.org/10.1083/jcb.201708053) use antibody tools that selectively recognize phosphorylated RII and the catalytic subunit active site to reexamine PKA holoenzyme activation mechanisms in neurons.

摘要

蛋白激酶 A（PKA）的 II 型调节亚基的自身磷酸化在其激活中的作用一直是一个悬而未决的问题。在本期杂志中，Isensee 等人（2018. https://doi.org/10.1083/jcb.201708053）使用了选择性识别磷酸化 RII 和催化亚基活性位点的抗体工具，重新研究了神经元中 PKA 全酶激活机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cae/5987730/4c5b142f87c4/JCB_201805011_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cae/5987730/4c5b142f87c4/JCB_201805011_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cae/5987730/4c5b142f87c4/JCB_201805011_Fig1.jpg

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Protein kinase A activation: Something new under the sun?蛋白激酶 A 的激活：日下新事？
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本文引用的文献

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PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination.PKA-RII 亚基磷酸化先于 cAMP 激活，并调节活性终止。
J Cell Biol. 2018 Jun 4;217(6):2167-2184. doi: 10.1083/jcb.201708053. Epub 2018 Apr 3.
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Local protein kinase A action proceeds through intact holoenzymes.局部蛋白激酶A的作用通过完整的全酶进行。
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FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility.
体育活动通过激活垂体腺苷酸环化酶激活肽（PACAP）和骨形态发生蛋白（BMP）信号通路来保护阿尔茨海默病肾脏的病理改变。
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GLP-1 Receptor Activation Abrogates β-Cell Dysfunction by PKA Cα-Mediated Degradation of Thioredoxin Interacting Protein.胰高血糖素样肽-1受体激活通过蛋白激酶A Cα介导的硫氧还蛋白相互作用蛋白降解消除β细胞功能障碍。
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cAMP regulation of protein phosphatases PP1 and PP2A in brain.cAMP 对脑内蛋白磷酸酶 PP1 和 PP2A 的调节作用。
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FRET 生物传感器揭示了 β-肾上腺素能靶点处的 cAMP 纳米区，这些纳米区决定了心脏收缩力的精确调节。
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Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme.蛋白激酶A RIIβ全酶的单周转自磷酸化循环
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Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase.与环磷酸腺苷依赖性蛋白激酶催化亚基结合的肽抑制剂的结构。
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