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Clinical efficacy of ruxolitinib and chemotherapy in a child with Philadelphia chromosome-like acute lymphoblastic leukemia with fusion and induction failure.

作者信息

Ding Yang Y, Stern Julie W, Jubelirer Tracey F, Wertheim Gerald B, Lin Fumin, Chang Fengqi, Gu Zhaohui, Mullighan Charles G, Li Yong, Harvey Richard C, Chen I-Ming, Willman Cheryl L, Hunger Stephen P, Li Marilyn M, Tasian Sarah K

机构信息

Children's Hospital of Philadelphia, Division of Oncology and Center for Childhood Cancer Research, PA, USA.

University of Pennsylvania Perelman School of Medicine, Department of Pediatrics, PA, USA.

出版信息

Haematologica. 2018 Sep;103(9):e427-e431. doi: 10.3324/haematol.2018.192088. Epub 2018 May 17.

DOI:10.3324/haematol.2018.192088
PMID:29773603
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6119161/
Abstract
摘要

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IKZF1 Defines a New Minimal Residual Disease-Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia.IKZF1 在小儿 B 细胞前体急性淋巴细胞白血病中定义了一种新的与微小残留病灶相关的非常差预后的最小残留病灶依赖性预后模型。
J Clin Oncol. 2018 Apr 20;36(12):1240-1249. doi: 10.1200/JCO.2017.74.3617. Epub 2018 Mar 2.
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Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group.高危B淋巴细胞白血病中可靶向的激酶基因融合：来自儿童肿瘤协作组的一项研究
Blood. 2017 Jun 22;129(25):3352-3361. doi: 10.1182/blood-2016-12-758979. Epub 2017 Apr 13.
3
High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults.成人费城染色体样急性淋巴细胞白血病的高频率及不良预后
J Clin Oncol. 2017 Feb;35(4):394-401. doi: 10.1200/JCO.2016.69.0073. Epub 2016 Nov 21.
4
Integration of ruxolitinib into dose-intensified therapy targeted against a novel JAK2 F694L mutation in B-precursor acute lymphoblastic leukemia.芦可替尼纳入针对B前体急性淋巴细胞白血病中一种新型JAK2 F694L突变的剂量强化疗法。
Pediatr Blood Cancer. 2017 May;64(5). doi: 10.1002/pbc.26328. Epub 2016 Nov 15.
5
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Blood. 2017 Jan 12;129(2):177-187. doi: 10.1182/blood-2016-05-707653. Epub 2016 Oct 24.
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Pediatr Blood Cancer. 2015 Oct;62(10):1717-24. doi: 10.1002/pbc.25575. Epub 2015 May 13.
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IgH-V(D)J NGS-MRD measurement pre- and early post-allotransplant defines very low- and very high-risk ALL patients.异基因移植前及移植后早期的免疫球蛋白重链可变区（IgH）-V（D）J下一代测序微小残留病（NGS-MRD）检测可明确极低风险和极高风险的急性淋巴细胞白血病（ALL）患者。
Blood. 2015 May 28;125(22):3501-8. doi: 10.1182/blood-2014-12-615757. Epub 2015 Apr 10.
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Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.Ph 样急性淋巴细胞白血病中可靶向的激酶激活病变。
N Engl J Med. 2014 Sep 11;371(11):1005-15. doi: 10.1056/NEJMoa1403088.