Liu Weiyu, Cao Yong, Guan Yadi, Zheng Changqing
Department of Gastroenterology, Shengjing Hospital of China Medical University, 39 Huaxiang Road, Shenyang, 110022, People's Republic of China.
Department of Gastroenterology, The People's Hospital of Liaoning Province, Shenyang, 110013, People's Republic of China.
Biotechnol Lett. 2018 Jul;40(7):1015-1027. doi: 10.1007/s10529-018-2562-z. Epub 2018 May 17.
To investigate the functional roles of bone marrow stromal cell antigen 2 (BST2) in gastric cancer (GC) cells and its implications in the development of GC patients.
BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demonstrated that knockdown of BST2 by siRNA inhibited cell proliferation, induced apoptosis and repressed cell motility in GC cells. In addition, the pro-tumor function of BST2 in GC was mediated partly through the NF-κB signaling.
BST2 possesses the oncogenic potential in GC by regulating the proliferation, apoptosis, and migratory ability of GC cells, thereby BST2 could be a potential therapeutic target for the treatment of GC.
探讨骨髓基质细胞抗原2（BST2）在胃癌（GC）细胞中的功能作用及其对GC患者病情发展的影响。
与癌旁非肿瘤组织相比，BST2在GC组织中常呈过表达，且BST2高表达与肿瘤分期及淋巴转移相关。此外，体外实验表明，通过小干扰RNA（siRNA）敲低BST2可抑制GC细胞的增殖、诱导凋亡并抑制细胞迁移。另外，BST2在GC中的促肿瘤功能部分是通过核因子κB（NF-κB）信号传导介导的。
BST2通过调节GC细胞的增殖、凋亡和迁移能力在GC中具有致癌潜能，因此BST2可能是GC治疗的潜在靶点。
