[白细胞介素-10、CD14和CD68在喉鳞状细胞癌中的表达及相关性]

[The expressions and correlations of IL-10, CD14 and CD68 in laryngal squamous cell carcinoma].

作者信息

Zhang S, Huangfu H, Wang B Q, Gao W, Wu L N, Li Y, Li W Y

机构信息

Department of Otolaryngology Head and Neck Surgery, the First Hospital of Shanxi Medical University, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Key Institute and Laboratory of Otolaryngology Affiliated with Shanxi Province, Taiyuan, 030001, China.

Department of Pathology, the First Hospital of Shanxi Medical University.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Jun 5;31(11):839-843. doi: 10.13201/j.issn.1001-1781.2017.11.006.

DOI:10.13201/j.issn.1001-1781.2017.11.006

PMID:29774998

Abstract

The aim of this study is to investigate the distribution of IL-10, CD14 and CD68 in the tumor microenvironment of LSCC with the clinicopathologic factors. We detected the expressions of IL-10, CD14 and CD68 in 46 primary LSCC tumor tissues by immunohistochemistry staining and explore the relationship between them and clinicopathologic factors. We found that the expressions of IL-10, CD14 and CD68 were significantly correlated with clinical stage and T stage (<0.01). IL-10 and CD14 were correlated with lymph node metastasis (<0.01), and CD68 was correlated with pathological differentiation (<0.05). There is a positive correlation trend between the expression of IL-10 and CD14 (<0.01). We confirm that the high level expressions of IL-10, monocytes and TAMs contribute to the tumor development of LSCC and there is a positive correlation between the expression of IL-10 and monocytes.

摘要

本研究旨在探讨白细胞介素-10（IL-10）、CD14和CD68在喉鳞状细胞癌（LSCC）肿瘤微环境中的分布及其与临床病理因素的关系。我们采用免疫组织化学染色法检测了46例原发性LSCC肿瘤组织中IL-10、CD14和CD68的表达，并探讨它们与临床病理因素之间的关系。我们发现，IL-10、CD14和CD68的表达与临床分期和T分期显著相关（<0.01）。IL-10和CD14与淋巴结转移相关（<0.01），CD68与病理分化相关（<0.05）。IL-10和CD14的表达之间存在正相关趋势（<0.01）。我们证实，IL-10、单核细胞和肿瘤相关巨噬细胞（TAMs）的高水平表达促进了LSCC的肿瘤发展，且IL-10与单核细胞的表达之间存在正相关。