Department of Otorhinolaryngology, Eulji Medical Center, Eulji University School of Medicine, Seoul, Republic of Korea.
Department of Otorhinolaryngology, Gyeongsang National University hospital, Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Head Neck. 2019 Jul;41(7):2058-2064. doi: 10.1002/hed.25654. Epub 2019 Jan 16.
This study's aim was to identify CD68 and stabilin-1 expressions and their prognostic implications in patients with oral cavity cancer (OCC).
Stabilin-1 and CD68 immunochemical staining was conducted in samples from patients with OCC who underwent curative surgery in our institute. We retrospectively analyzed patients' clinical information. We investigated the relationship between CD68 and stabilin-1 expression levels and their effect on prognostic factors and survival.
Fifty-four patients' data were analyzed. CD68 and stabilin-1 expressions were positively correlated (P = .008). CD68 and stabilin-1 expressions were not correlated with other prognostic factors (eg, T classification or lymph node metastasis). Stabilin-1 expression and tumor recurrence risk were positively correlated (P = .015). CD68 expression was neither associated with recurrence-free nor OCC-specific survival.
CD68 and stabilin-1 expressions in OCC were positively correlated. Stabilin-1 expression was significantly associated with OCC recurrence risk, but the prognostic value of CD68 was not confirmed.
本研究旨在探讨口腔癌（OCC）患者中 CD68 和稳定素-1 的表达及其预后意义。
对在我院接受根治性手术的 OCC 患者的样本进行了稳定素-1 和 CD68 免疫化学染色。我们回顾性分析了患者的临床资料。研究了 CD68 和稳定素-1 表达水平之间的关系及其对预后因素和生存的影响。
分析了 54 例患者的数据。CD68 和稳定素-1 的表达呈正相关（P=0.008）。CD68 和稳定素-1 的表达与其他预后因素（如 T 分类或淋巴结转移）无关。稳定素-1 的表达与肿瘤复发风险呈正相关（P=0.015）。CD68 的表达与无复发生存或 OCC 特异性生存均无关。
OCC 中 CD68 和稳定素-1 的表达呈正相关。稳定素-1 的表达与 OCC 的复发风险显著相关，但 CD68 的预后价值尚未得到证实。
