de Boer H H Hans, Maat G J R George
Dept. of Pathology, Academic Medical Center, Amsterdam, The Netherlands; Barge's Anthropologica-Amsterdam, Dept. of Anatomy, Embryology and Physiology, Academic Medical Center, Amsterdam, The Netherlands.
Barge's Anthropologica-Leiden, Dept. of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands.
Int J Paleopathol. 2018 Jun;21:56-63. doi: 10.1016/j.ijpp.2016.11.005. Epub 2016 Dec 6.
This article focuses on the application of dry bone histology in the diagnosis of a series of different bone tumours. It provides a short introduction on bone tumour classification and how tumours may affect the skeleton. To illustrate the value of dry bone histology in the diagnostic process we studied the 'fresh' and 'dry' bone histology of a series of well-documented, recent clinical cases of various benign and malignant bone tumours. We show that histology is a valuable instrument to assess bone tissue architecture, which provides information on the biological behaviour of a tumour. Though histology may reveal the specific 'tumorous' bone deposition of high-grade conventional osteosarcomas, all other bone tumours display common, unspecific features. This holds for the following tumours: osteochondroma, hyperostotic meningioma, high-grade angiosarcoma, grade 2 chondrosarcoma, myoepithelial carcinoma, high-grade osteosarcoma and four carcinoma metastases. We conclude that histology is useful in cases where the biological behaviour of a tumour is to be defined, and is particularly an aide in the diagnosis of high-grade conventional osteosarcomas. Nevertheless, the differential diagnosis on the bone tumours in our series should primarily be based on a combination of physical anthropological patient data (age, sex), gross anatomy (e.g. tumour morphology and location), and radiography.
本文重点介绍干骨组织学在一系列不同骨肿瘤诊断中的应用。它简要介绍了骨肿瘤分类以及肿瘤如何影响骨骼。为了说明干骨组织学在诊断过程中的价值，我们研究了一系列记录完备的近期各种良性和恶性骨肿瘤临床病例的“新鲜”和“干”骨组织学。我们表明，组织学是评估骨组织结构的重要工具，可提供有关肿瘤生物学行为的信息。尽管组织学可能揭示高级别传统骨肉瘤的特定“肿瘤性”骨沉积，但所有其他骨肿瘤均表现出常见的非特异性特征。以下肿瘤均是如此：骨软骨瘤、骨肥厚性脑膜瘤、高级别血管肉瘤、2级软骨肉瘤、肌上皮癌、高级别骨肉瘤以及四种癌转移瘤。我们得出结论，组织学在确定肿瘤生物学行为的病例中很有用，尤其有助于高级别传统骨肉瘤的诊断。然而，我们系列中骨肿瘤的鉴别诊断应主要基于体质人类学患者数据（年龄、性别）、大体解剖（如肿瘤形态和位置）以及放射学检查的综合结果。
