Moroncini Gianluca, Benfaremo Devis, Mandolesi Alessandra, Gabrielli Armando
Dipartimento Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy.
Clinica Medica, AOU Ospedali Riuniti di Ancona, Ancona, Italy.
BMJ Case Rep. 2018 May 18;2018:bcr-2018-224829. doi: 10.1136/bcr-2018-224829.
We present the case of a 44-year-old woman affected by systemic sclerosis (SSc) who was admitted to our department for abdominal pain, nausea, vomiting and fever. Imaging studies showed the presence of a thickened colon wall involving the descending colon and the sigma, while a subsequent endoscopy revealed multiple serpiginous ulcers covered with fibrin and exudates. Under the hypothesis of drug-induced colitis, mycophenolate mofetil (MMF), which she was taking for SSc-related interstitial lung disease (ILD), was readily suspended, with a rapid recovery without further treatment. A follow-up colonoscopy showed the complete resolution of the ulcers. This is the first case of MMF-induced colitis in a patient being treated for SSc-ILD.
我们报告了一例44岁患有系统性硬化症（SSc）的女性病例，该患者因腹痛、恶心、呕吐和发热入住我科。影像学检查显示降结肠和乙状结肠肠壁增厚，随后的内镜检查发现多处匐行性溃疡，表面覆盖有纤维蛋白和渗出物。在药物性结肠炎的假设下，她因SSc相关间质性肺病（ILD）正在服用的霉酚酸酯（MMF）被立即停用，未经进一步治疗便迅速康复。随访结肠镜检查显示溃疡完全愈合。这是首例在接受SSc-ILD治疗的患者中发生MMF诱导性结肠炎的病例。
