Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, 1400 NW 10th Ave., Miami, FL, 33136, USA.
Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, USA.
J Behav Med. 2018 Dec;41(6):792-797. doi: 10.1007/s10865-018-9935-6. Epub 2018 May 17.
Methamphetamine and HIV impair thyroid function, but few studies have investigated their combined effects on thyroid dysregulation. This study examined the associations of methamphetamine use alone and in combination with HIV on thyroid function among men in South Florida. Measures of thyroid function in methamphetamine-using, HIV-infected (METH+HIV+; n = 127) and HIV-negative (METH+HIV-; n = 46) men who have sex with men (MSM) were compared to non-methamphetamine-using, HIV-negative men (METH-HIV-; n = 136). Thyroid function was dysregulated in methamphetamine-using MSM, irrespective of HIV status. Both meth-using groups had greater odds of abnormal thyroid stimulating hormone levels and significantly higher mean free triiodothyronine (T3) levels. Elevated free T3 was associated with greater depressive symptoms. Overall, outcomes have important implications for assessment of thyroid function in methamphetamine users, particularly among those presenting with depression.
冰毒和 HIV 会损害甲状腺功能，但很少有研究调查它们对甲状腺功能紊乱的联合影响。本研究调查了在南佛罗里达州的男男性行为者中，单独使用冰毒和同时感染 HIV 对甲状腺功能的影响。与未使用冰毒且 HIV 阴性的男男性行为者（METH-HIV-；n=136）相比，比较了单独使用冰毒且感染 HIV（METH+HIV+；n=127）和 HIV 阴性（METH+HIV-；n=46）的冰毒使用者的甲状腺功能指标。无论 HIV 状况如何，使用冰毒的男男性行为者的甲状腺功能都出现紊乱。使用冰毒的两组人群促甲状腺激素水平异常的几率更大，游离三碘甲状腺原氨酸（T3）水平明显更高。游离 T3 升高与更严重的抑郁症状相关。总的来说，这些结果对评估冰毒使用者的甲状腺功能具有重要意义，尤其是对那些出现抑郁症状的人。
