Health Services Research Unit, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain; Pompeu Fabra University (UPF), Barcelona, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Queensland Centre for Mental Health Research, University of Queensland, St. Lucia, Queensland, Australia; Queensland Brain Institute, University of Queensland, St. Lucia, Queensland, Australia.
Schizophr Res. 2018 Nov;201:46-53. doi: 10.1016/j.schres.2018.04.044. Epub 2018 May 16.
Psychotic experiences (PEs) are associated with a range of mental and physical disorders, and disability, but little is known about the association between PEs and aspects of health-related quality of life (HRQoL). We aimed to investigate the association between PEs and five HRQoL indicators with various adjustments. Using data from the WHO World Mental Health surveys (n = 33,370 adult respondents from 19 countries), we assessed for PEs and five HRQoL indicators (self-rated physical or mental health, perceived level of stigma (embarrassment and discrimination), and social network burden). Logistic regression models that adjusted for socio-demographic characteristics, 21 DSM-IV mental disorders, and 14 general medical conditions were used to investigate the associations between the variables of interest. We also investigated dose-response relationships between PE-related metrics (number of types and frequency of episodes) and the HRQoL indicators. Those with a history of PEs had increased odds of poor perceived mental (OR = 1.5, 95% CI = 1.2-1.9) and physical health (OR = 1.3, 95% CI = 1.0-1.7) after adjustment for the presence of any mental or general medical conditions. Higher levels of perceived stigma and social network burden were also associated with PEs in the adjusted models. Dose-response associations between PE type and frequency metrics and subjective physical and mental health were non-significant, except those with more PE types had increased odds of reporting higher discrimination (OR = 2.2, 95% CI = 1.3-3.5). Our findings provide novel insights into how those with PEs perceive their health status.
精神体验（PEs）与一系列精神和身体障碍以及残疾有关，但人们对 PEs 与健康相关生活质量（HRQoL）的各个方面之间的关联知之甚少。我们旨在调查 PEs 与五个 HRQoL 指标之间的关联，并进行了各种调整。我们使用来自世界卫生组织（WHO）世界心理健康调查的数据（来自 19 个国家的 33370 名成年受访者），评估了 PEs 和五个 HRQoL 指标（自我评估的身体或心理健康、感知的耻辱感（尴尬和歧视）水平以及社交网络负担）。我们使用调整了社会人口统计学特征、21 种 DSM-IV 精神障碍和 14 种一般医疗状况的逻辑回归模型来调查感兴趣变量之间的关联。我们还调查了与 PE 相关的指标（类型数量和发作频率）与 HRQoL 指标之间的剂量反应关系。在调整任何精神或一般医疗状况存在的情况下，有 PEs 病史的人感知到的心理健康（OR=1.5，95%CI=1.2-1.9）和身体健康（OR=1.3，95%CI=1.0-1.7）较差的可能性增加。在调整后的模型中，感知到的耻辱感和社交网络负担水平较高也与 PEs 相关。PE 类型和频率指标与主观身体和心理健康之间的剂量反应关系不显著，但那些有更多 PE 类型的人报告更高的歧视（OR=2.2，95%CI=1.3-3.5）的可能性增加。我们的研究结果提供了有关 PEs 如何影响人们感知健康状况的新见解。
