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促性腺激素释放激素激动剂、人绒毛膜促性腺激素（hCG）、孕激素和雌激素在 hCG 触发后的黄体期支持中的作用，以及在妊娠时何时可以停止激素支持。

Role of gonadotropin-releasing hormone agonists, human chorionic gonadotropin (hCG), progesterone, and estrogen in luteal phase support after hCG triggering, and when in pregnancy hormonal support can be stopped.

机构信息

Department of Obstetrics, Gynecology, and Reproductive Medicine, Hopital Foch-Faculté de Médecine Paris Ouest (UVSQ), Suresnes, France.

Department of Obstetrics, Gynecology, and Reproductive Medicine, Hopital Foch-Faculté de Médecine Paris Ouest (UVSQ), Suresnes, France.

出版信息

Fertil Steril. 2018 May;109(5):749-755. doi: 10.1016/j.fertnstert.2018.03.006.

DOI:10.1016/j.fertnstert.2018.03.006
PMID:29778367
Abstract

Luteal phase support is mandatory in ovarian stimulation cycles in assisted reproductive technology owing to a deficit in LH pulsatility after the effects of exogenous hCG-used for triggering ovulation-vanish. This is classically accomplished by means of exogenous P administration, but emerging new options include microdoses of hCG and exogenous GnRH agonist. Although luteal phase support is commonly continued for up to 10 weeks into pregnancy, there is accumulating evidence that it can be stopped after the first ultrasound or even after a positive pregnancy test.

摘要

黄体支持是辅助生殖技术中卵巢刺激周期所必需的，因为在用于触发排卵的外源性 hCG 作用消失后，LH 脉冲性会出现不足。这通常通过外源性孕激素（P）给药来实现，但新出现的选择包括小剂量 hCG 和外源性 GnRH 激动剂。虽然黄体支持通常会持续到怀孕 10 周，但越来越多的证据表明，它可以在第一次超声检查后甚至在怀孕测试阳性后停止。

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