Wellcome Sanger Institute, Hinxton CB10 1SA, UK; Current address: Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK.
Institute of Computer Science, University of Tartu, 50409 Tartu, Estonia.
Trends Cell Biol. 2018 Jul;28(7):509-511. doi: 10.1016/j.tcb.2018.04.009. Epub 2018 May 16.
Recent studies involving induced pluripotent stem cell (iPSC) reprogramming in mice and monocyte-to-macrophage differentiation in humans have revealed a role for the transcription factor (TF) activator protein 1 (AP-1) in chromatin accessibility. Enhancer selection may be determined not only by cell type-specific sets of TFs but also by broadly expressed ones like AP-1.
最近的研究涉及在小鼠中进行诱导多能干细胞（iPSC）重编程以及在人类中进行单核细胞向巨噬细胞分化，这些研究揭示了转录因子（TF）激活蛋白 1（AP-1）在染色质可及性中的作用。增强子选择可能不仅由细胞类型特异性的 TF 集决定，还可能由广泛表达的 TF 如 AP-1 决定。
