左氧氟沙星还要用吗？左氧氟沙星致精神障碍 1 例报告。

Leave the levofloxacin? A case report of levofloxacin-induced psychosis.

机构信息

Department of Pharmacy, Loyola University Medical Center, United States.

Department of Emergency Medicine, Loyola University Medical Center, United States.

出版信息

Am J Emerg Med. 2018 Aug;36(8):1528.e1-1528.e2. doi: 10.1016/j.ajem.2018.05.026. Epub 2018 May 18.

DOI:10.1016/j.ajem.2018.05.026

PMID:29779676

Abstract

Fluoroquinolones, including levofloxacin, exhibit desirable antimicrobial characteristics, including broad spectrum of activity and excellent bioavailability. This widely prescribed class of antibiotics has come under scrutiny due to a new black box warning of adverse reactions. Central nervous system effects have been sparsely described in previous literature. We present a case of levofloxacin-induced psychosis in a patient without underlying psychological history.

摘要

氟喹诺酮类药物，包括左氧氟沙星，具有理想的抗菌特性，包括广谱活性和良好的生物利用度。由于新的不良反应黑框警告，这种广泛应用的抗生素类别受到了严格审查。以前的文献中很少描述中枢神经系统的影响。我们报告了一例无潜在心理病史的左氧氟沙星诱导的精神病病例。