Tiwananthagorn Saruda, Srivorakul Saralee, Khochakul Varangpicha, Pringproa Kidsadagon
Department of Veterinary Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, 50100, Thailand; Center of Excellence in Veterinary Bioscience, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, 50100, Thailand.
Veterinary Diagnostic Laboratory, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, 50100, Thailand.
Vet Parasitol. 2018 Jul 15;258:138-141. doi: 10.1016/j.vetpar.2018.05.001. Epub 2018 May 5.
A 12-year-old, female, domestic cat (Felis catus) presented with dehydration, emaciation, anorexia, and lethargy. The cat was unresponsive to medical treatment and euthanized; the carcass was submitted for pathological diagnosis. Necropsy revealed icteric mucous membranes. The liver was enlarged, with multinodular, cystic, white masses, 0.5-4.0 cm in diameter, scattered throughout. Microscopically, the biliary epithelium presented with a proliferation of multifocal cystic masses, occasionally with periodic acid-Schiff-positive fluid within the cysts. Simple cuboidal epithelial cells showed small, round to oval, vesicular nuclei and rare mitotic figures. There were also multifocal trematode-like parasites situated within the biliary tracts. Immunohistochemistry of the cystic masses was positive for pan-cytokeratin and proliferating cell nuclear antigen, while negative for vimentin. Molecular analysis and gene sequencing of the parasite indicated that it was Opisthorchis viverrini. Based on the pathological findings and molecular analysis, the cat was diagnosed with biliary cystadenoma related to O. viverrini infection. This report described an unusual case of O. viverrini infection associated with biliary tumor in a cat, and raises the possibility of domestic cats as a reservoir host of the human liver fluke.
一只12岁的雌性家猫（Felis catus）出现脱水、消瘦、厌食和嗜睡症状。这只猫对药物治疗无反应，最终实施安乐死；其尸体被送去做病理诊断。尸检发现黏膜黄疸。肝脏肿大，有多个直径为0.5 - 4.0厘米的结节状、囊性白色肿块，散在分布。显微镜下，胆管上皮呈现多灶性囊性肿块增生，囊肿内偶尔有过碘酸希夫染色阳性液体。单层立方上皮细胞显示小的、圆形至椭圆形的泡状核，有罕见的有丝分裂象。胆管内还存在多灶性吸虫样寄生虫。囊肿性肿块的免疫组织化学检测显示，泛细胞角蛋白和增殖细胞核抗原呈阳性，波形蛋白呈阴性。对该寄生虫的分子分析和基因测序表明它是猫后睾吸虫。根据病理结果和分子分析，这只猫被诊断为与猫后睾吸虫感染相关的胆管囊腺瘤。本报告描述了一例猫后睾吸虫感染伴发胆管肿瘤的罕见病例，并提出家猫作为人类肝吸虫储存宿主的可能性。
