Sánchez-Garibay Carlos, Hernández-Campos María Elena, Tena-Suck Martha Lilia, Salinas-Lara Citlaltepetl
Departamento de Neuropatología, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico; Doctorado en Investigación en Medicina, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico.
Doctorado en Investigación en Medicina, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico.
Tuberculosis (Edinb). 2018 May;110:1-6. doi: 10.1016/j.tube.2018.02.007. Epub 2018 Feb 25.
Animal models are and will remain valuable tools in medical research because their use enables a deeper understanding of disease development, thus generating important knowledge for developing disease control strategies. Central nervous system tuberculosis (CNS TB) is the most devastating disease in humans. Moreover, as the variability of signs and symptoms delay a timely diagnosis, patients usually arrive at the hospital suffering from late stage disease. Therefore, it is impossible to obtain fresh human tissue for research before an autopsy. Because of these reasons, studies on human CNS TB are limited to case series, pharmacological response reports, and post mortem histopathological studies. Here, we review the contribution of the different animal models to understand the immunopathology of the disease and the host-parasitic relationship, as well as in the development of new strategies of vaccination and to test new drugs for the treatment of CNS TB.
动物模型在医学研究中一直都是且仍将是有价值的工具，因为使用它们能够更深入地了解疾病发展过程，从而为制定疾病控制策略积累重要知识。中枢神经系统结核病（CNS TB）是人类最具毁灭性的疾病。此外，由于症状和体征的变异性会延误及时诊断，患者通常在疾病晚期才到医院就诊。因此，在尸检前无法获取新鲜的人体组织用于研究。由于这些原因，关于人类中枢神经系统结核病的研究仅限于病例系列、药理反应报告以及死后组织病理学研究。在此，我们综述了不同动物模型在理解该疾病的免疫病理学和宿主 - 寄生虫关系方面的贡献，以及在开发新的疫苗接种策略和测试治疗中枢神经系统结核病的新药方面的贡献。
