INSERM U932, Institut Curie, ANR-10-IDEX-0001-02 PSL* and ANR-11-LABX-0043, Paris, France.
Institut Curie, PSL Research University, CNRS, UMR 144, F-75005 Paris, France; Institut Pierre-Gilles de Gennes, PSL Research University, F-75005 Paris, France.
Trends Immunol. 2018 Aug;39(8):632-643. doi: 10.1016/j.it.2018.04.007. Epub 2018 May 17.
The function of most immune cells depends on their ability to migrate through complex microenvironments, either randomly to patrol for the presence of antigens or directionally to reach their next site of action. The actin cytoskeleton and its partners are key conductors of immune cell migration as they control the intrinsic migratory properties of leukocytes as well as their capacity to respond to cues present in their environment. In this review we focus on the latest discoveries regarding the role of the actomyosin cytoskeleton in optimizing immune cell migration in complex environments, with a special focus on recent insights provided by physical modeling.
大多数免疫细胞的功能取决于它们穿过复杂微环境的迁移能力，无论是随机巡逻以检测抗原的存在，还是定向迁移以到达下一个作用部位。肌动蛋白细胞骨架及其伴侣是免疫细胞迁移的关键导体，因为它们控制着白细胞的固有迁移特性及其对环境中存在的信号的响应能力。在这篇综述中，我们专注于最新发现，即肌动球蛋白细胞骨架在优化复杂环境中的免疫细胞迁移中的作用，特别关注物理建模提供的最新见解。
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