Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
Department of Dermatology, Medical University of Vienna, Vienna, Austria.
Front Immunol. 2021 Nov 15;12:750537. doi: 10.3389/fimmu.2021.750537. eCollection 2021.
Motility is a crucial activity of immune cells allowing them to patrol tissues as they differentiate, sample or exchange information, and execute their effector functions. Although all immune cells are highly migratory, each subset is endowed with very distinct motility patterns in accordance with functional specification. Furthermore individual immune cell subsets adapt their motility behaviour to the surrounding tissue environment. This review focuses on how the generation and adaptation of diversified motility patterns in immune cells is sustained by actin cytoskeleton dynamics. In particular, we review the knowledge gained through the study of inborn errors of immunity (IEI) related to actin defects. Such pathologies are unique models that help us to uncover the contribution of individual actin regulators to the migration of immune cells in the context of their development and function.
运动性是免疫细胞的一项关键活动，使它们能够在分化过程中巡逻组织，取样或交换信息，并执行其效应功能。虽然所有免疫细胞的迁移能力都很强，但每个亚群都根据功能特异性赋予了非常独特的运动模式。此外，单个免疫细胞亚群会根据周围组织环境来调整其运动行为。本篇综述重点关注免疫细胞中多样化运动模式的产生和适应如何通过肌动蛋白细胞骨架动力学来维持。特别是，我们回顾了通过研究与肌动蛋白缺陷相关的先天性免疫缺陷（IEI）获得的知识。此类病理是独特的模型，可帮助我们在免疫细胞的发育和功能背景下，发现各个肌动蛋白调节剂对其迁移的贡献。
