三种大鼠品系对血清素激动剂的摄食和运动反应比较。

A comparison of feeding and locomotion responses to serotonin agonists in three rat strains.

作者信息

Aulakh C S, Hill J L, Murphy D L

机构信息

Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892.

出版信息

Pharmacol Biochem Behav. 1988 Nov;31(3):567-71. doi: 10.1016/0091-3057(88)90231-6.

DOI:10.1016/0091-3057(88)90231-6

PMID:2977992

Abstract

The hyperphagic effects of two selective 5-HT1A agonists (8-OHDPAT and buspirone) in a free feeding paradigm and the locomotor suppressant effect of the serotonin agonist, m-chlorophenylpiperazine (m-CPP) were compared in three different rat strains: Wistar, Sprague-Dawley (SD), and Fawn-Hooded (FH) rats. Administration of various doses of 8-OHDPAT and buspirone produced significant increases in two-hour food intake only in Wistar and SD strains and not in the FH strain. Similarly, various doses of m-CPP produced significant decreases in locomotor activity only in Wistar and SD strains and not in the FH strain. Isolated FH animals gained significantly less body weight relative to both Wistar and SD animals. These findings demonstrate attenuated feeding and behavioral responses to serotonergic agonists in the FH strain relative to both Wistar and SD strains.

摘要

在自由进食模式下，比较了两种选择性5-羟色胺1A（5-HT1A）激动剂（8-羟基二丙胺四乙酸（8-OHDPAT）和丁螺环酮）的摄食亢进效应，以及5-羟色胺激动剂间氯苯哌嗪（m-CPP）对三种不同品系大鼠的运动抑制效应：Wistar大鼠、斯普拉格-道利（SD）大鼠和淡色带帽（FH）大鼠。给予不同剂量的8-OHDPAT和丁螺环酮后，仅Wistar大鼠和SD大鼠的两小时食物摄入量显著增加，而FH大鼠则未增加。同样，不同剂量的m-CPP仅使Wistar大鼠和SD大鼠的运动活性显著降低，而FH大鼠则未降低。相对于Wistar大鼠和SD大鼠，单独饲养的FH大鼠体重增加明显较少。这些发现表明，相对于Wistar大鼠和SD大鼠，FH品系大鼠对5-羟色胺能激动剂的摄食和行为反应减弱。