通过OSMAC策略从sp. ZJ-M-5中分离得到的三种新聚酮化合物。
Three new polyketides from sp. ZJ-M-5 by the OSMAC strategy.
作者信息
Dong Ya-Jing, Hou Guo-Mei, Lin Bin, Li Dan-Yi, Li Zhan-Lin
机构信息
a Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
b School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
出版信息
J Asian Nat Prod Res. 2019 Jul;21(7):689-695. doi: 10.1080/10286020.2018.1471066. Epub 2018 May 21.
Three new compounds, ascotrichols A-B () and ascotrichrone A (), along with two known isocoumarin derivatives (), were isolated from the solid culture of a sea mud-derived fungus, sp. ZJ-M-5 on rice media. The structures were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR data, and the absolute configurations were determined by electronic circular dichroism and biogenetic correlation.
从海洋淤泥来源的真菌ZJ-M-5在大米培养基上的固体培养物中分离出三种新化合物，即曲霉三醇A - B（）和曲霉色酮A（），以及两种已知的异香豆素衍生物（）。通过广泛的光谱分析，包括一维和二维核磁共振数据对其结构进行了阐明，并通过电子圆二色性和生源关系确定了绝对构型。
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