海绵来源真菌 sp. SCSIO 41421 的新型羧酰胺和新型聚酮。
New Carboxamides and a New Polyketide from the Sponge-Derived Fungus sp. SCSIO 41421.
机构信息
CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
出版信息
Mar Drugs. 2022 Jul 25;20(8):475. doi: 10.3390/md20080475.
New carboxamides, (±)-vochysiamide C () and (+)-vochysiamide B (), and a new polyketide, 4,3a,9a-3a,9a-deoxy-3a hydroxy-1-dehydroxyarthrinone (), were isolated and identified from the sponge-derived fungus sp. SCSIO 41421, together with other fifteen known natural products (-). Their structures including absolute configurations were determined by detailed NMR, MS spectroscopic analyses, calculated electronic circular dichroism (ECD), as well as quantum-chemical NMR calculations. Preliminary bioactivity screening and molecular docking analysis revealed that several natural products exhibited obvious enzyme inhibitory activities against acetylcholinesterase (AChE), such as 2,3,6,8-tetrahydroxy-1-methylxanthone () with an inhibitory rate 86% at 50 μg/mL.
从海绵来源的真菌 sp. SCSIO 41421 中分离鉴定得到三个新化合物，包括两个新的羧酰胺类化合物（±）-vochysiamide C () 和 (+)-vochysiamide B ()，以及一个新的聚酮化合物 4,3a,9a-3a,9a-deoxy-3a-hydroxy-1-dehydroxyarthrinone ()，此外还分离鉴定了其他十五个已知天然产物 (-)。通过详细的 NMR、MS 光谱分析、计算电子圆二色性 (ECD) 以及量子化学 NMR 计算确定了它们的结构，包括绝对构型。初步的生物活性筛选和分子对接分析表明，几种天然产物对乙酰胆碱酯酶 (AChE) 具有明显的抑制活性，例如 2,3,6,8-四羟基-1-甲基黄烷酮 ()，在 50 μg/mL 时抑制率为 86%。
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