Hamann A, Jablonski-Westrich D, Harder R, Thiele H G
Abt. f. klin. Immunologie, Univ. krankenhaus, Hamburg, F.R.G.
Adv Exp Med Biol. 1988;237:511-8. doi: 10.1007/978-1-4684-5535-9_78.
The experiments show that homing receptors are regulated in a complex fashion during initial cellular activation: Signals leading to blast formation induced either: --a decrease of homing receptor expression in the majority of blasts; --an increase of the Mel-14 expression in 20-40% of the blasts, and --a selective down-regulation in the capacity to bind to Peyer's patch HEV even under conditions, where binding to peripheral HEV is high. Submitogenic stimuli in partially activated cultures induce a rise in Mel-14 antigen expression and binding to peripheral node HEV, whereas Peyer's patch binding is unchanged or lowered. Thus, a selective and differential regulation of organ-specific homing receptors takes place under distinct activation conditions. The mucosal system-related receptor is more easily down-regulated upon activation. The in vivo homing experiments indicate that mitogen activation induces one dominant migratory phenotype. Alterations in homing receptor expression seem to be associated with changes in further cellular functions leading to reduced entry into lymphatic tissues and increased localization of these cells in lung or liver. The mechanisms regulating the differential expression of organ-specific homing receptors and additional homing-relevant properties of the cells are still unknown.
实验表明，在初始细胞激活过程中，归巢受体以复杂的方式受到调节：导致母细胞形成的信号会诱导以下情况：——大多数母细胞中归巢受体表达降低；——20%-40%的母细胞中Mel-14表达增加；——即使在与外周高内皮微静脉结合能力较高的条件下，与派尔集合淋巴结高内皮微静脉结合的能力也会选择性下调。部分激活培养物中的亚致有丝分裂刺激会诱导Mel-14抗原表达增加以及与外周淋巴结高内皮微静脉结合，而与派尔集合淋巴结的结合则保持不变或降低。因此，在不同的激活条件下，会发生器官特异性归巢受体的选择性和差异性调节。与黏膜系统相关的受体在激活时更容易下调。体内归巢实验表明，有丝分裂原激活会诱导一种主要的迁移表型。归巢受体表达的改变似乎与进一步的细胞功能变化有关，导致进入淋巴组织的细胞减少，这些细胞在肺或肝脏中的定位增加。调节器官特异性归巢受体差异表达以及细胞其他归巢相关特性的机制仍然未知。
