Ross J A, Howie S E, Norval M, Maingay J P
Department of Clinical and Laboratory Haematology, Western General Hospital, Edinburgh, Scotland.
Viral Immunol. 1987;1(3):191-8. doi: 10.1089/vim.1987.1.191.
Urocanic acid (UCA), the putative photoreceptor for ultraviolet radiation (UV)-induced suppression, undergoes a UV-dependent trans to cis isomerisation. Epidermal cells from mice painted with UCA, containing a known proportion of the cis-isomer, generate suppression of the delayed type hypersensitivity response to herpes simplex virus type 1 (HSV-1) when transferred to naive syngeneic recipients at the same time and site as infection with HSV-1. One T suppressor cell subset, of phenotype (Thy1+, L3T4+, Ly2-), is induced by the cis-UCA modified epidermal cell transfer. Flow cytometric analysis of the epidermal cells from skin treated with UV or cis-UCA indicates an overall reduction from normal in the number of cells expressing MHC Class II antigens, but no alteration in the number expressing I-J antigens.
尿刊酸（UCA）是紫外线（UV）诱导免疫抑制的假定光感受器，会发生紫外线依赖的反式到顺式异构化。用含有已知比例顺式异构体的UCA涂抹的小鼠表皮细胞，当在与单纯疱疹病毒1型（HSV-1）感染相同的时间和部位转移到同基因的未致敏受体时，会对HSV-1产生迟发型超敏反应的抑制。一种表型为（Thy1 +、L3T4 +、Ly2 -）的T抑制细胞亚群由顺式-UCA修饰的表皮细胞转移诱导产生。对经紫外线或顺式-UCA处理的皮肤的表皮细胞进行流式细胞术分析表明，表达MHC II类抗原的细胞数量总体上比正常减少，但表达I-J抗原的细胞数量没有改变。
