心输出量对老年患者罗库溴铵诱导的神经肌肉阻滞起效的影响。
Effects of cardiac output on the onset of rocuronium-induced neuromuscular block in elderly patients.
机构信息
Department of Anesthesiology, School of Medicine, International University of Medical and Welfare, Tokyo, Japan.
Department of Anesthesiology, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi-Ku, Tokyo, 173-8610, Japan.
出版信息
J Anesth. 2018 Aug;32(4):547-550. doi: 10.1007/s00540-018-2510-z. Epub 2018 May 21.
PURPOSE
The aim of this study was to elucidate the relationship between the onset of rocuronium-induced neuromuscular block and arterial pressure-based cardiac output (CO) in elderly patients.
METHODS
Forty elderly patients aged 65-83 years were enrolled in this study. After induction of anesthesia, contractions of the adductor pollicis muscle to ulnar nerve train-of-four stimulation were acceleromyographically evaluated and 1 mg/kg rocuronium was administered following CO measurement. The correlation between onset of rocuronium action and CO was analyzed.
RESULTS
The mean [SD] CO reduced after induction of anesthesia from 5.1 [1.8] L/min to 3.8 [1.1] L/min. The onset time of rocuronium-induced neuromuscular block was 110.3 [23.9] s (range 60-165). There was a statistically significant inverse correlation between the onset time of rocuronium and CO [onset time (s) = - 13.2·CO + 159.7, R = 0.376].
CONCLUSIONS
In the elderly, CO influences the onset of action of rocuronium.
目的
本研究旨在阐明罗库溴铵诱导的神经肌肉阻滞的发作与老年患者基于动脉压的心输出量（CO）之间的关系。
方法
本研究纳入了 40 名年龄在 65-83 岁的老年患者。麻醉诱导后，通过加速度描记法评估拇内收肌对尺神经四脉冲串刺激的收缩，并在 CO 测量后给予 1mg/kg 罗库溴铵。分析罗库溴铵作用的起始与 CO 之间的相关性。
结果
麻醉诱导后 CO 的平均值[标准差]从 5.1[1.8]L/min 降低至 3.8[1.1]L/min。罗库溴铵诱导的神经肌肉阻滞的起始时间为 110.3[23.9]s（范围 60-165）。罗库溴铵的起始时间与 CO 之间存在统计学上显著的负相关[起始时间（s）= -13.2·CO + 159.7，R=0.376]。
结论
在老年人中，CO 影响罗库溴铵的作用起始。
Zotero 插件