Surachetpong Sirilak Disatian, Teewasutrakul Patarakrit, Rungsipipat Anudep
Jpn J Vet Res. 2016 Nov;64(4):221-233.
The study aimed to evaluate whether cardiac troponin I (cTnI) and pulsed-wave tissue Doppler imaging (TDI) measurements can detect cardiac changes during doxorubicin therapy in dogs with various types of cancers compared to conventional echocardiography. Serial measurements of cTnI and conventional and pulsed-wave TDI echocardiography were performed in 12 dogs diagnosed with various types of cancers at day 0, weeks 3, 6, 9, and 12 prior to each doxorubicin injection. After treatment with doxorubicin, dogs had significantly increased cTnI levels at week 9 (p = 0.027) and 12 (p = 0.027) compared to normal untreated dogs. Dogs had increased cTnI levels during doxorubicin therapy (p = 0.004). Percent left ventricular ejection fraction (LVEF) and fractional shortening (FS) assessed by 2-dimensional and M-mode echocardiography significantly decreased at weeks 9 and 12. Pulsed-wave TDI derived myocardial performance index (MPI) increased significantly at weeks 9 and 12 compared to day 0 (p = 0.028 and 0.040, respectively). In conclusion, dogs treated with doxorubicin had increased cTnI levels. An increase in cTnI levels was detected before echocardiographic value changes. Serum cTnI can be a sensitive marker for detection of cardiotoxicity in dogs treated with doxorubicin.
本研究旨在评估与传统超声心动图相比，心肌肌钙蛋白I（cTnI）和脉冲波组织多普勒成像（TDI）测量能否检测患有各种癌症的犬在阿霉素治疗期间的心脏变化。在每次阿霉素注射前的第0天、第3周、第6周、第9周和第12周，对12只诊断患有各种癌症的犬进行cTnI以及传统和脉冲波TDI超声心动图的系列测量。与未接受治疗的正常犬相比，阿霉素治疗后的犬在第9周（p = 0.027）和第12周（p = 0.027）时cTnI水平显著升高。犬在阿霉素治疗期间cTnI水平升高（p = 0.004）。通过二维和M型超声心动图评估的左心室射血分数（LVEF）百分比和缩短分数（FS）在第9周和第12周时显著降低。与第0天相比，脉冲波TDI得出的心肌性能指数（MPI）在第9周和第12周时显著升高（分别为p = 0.028和0.040）。总之，接受阿霉素治疗的犬cTnI水平升高。在超声心动图值变化之前就检测到了cTnI水平的升高。血清cTnI可以作为检测接受阿霉素治疗的犬心脏毒性的敏感标志物。
