De Simone Emanuele, Di Micco Lucia, La Manna Gaetano, Di Iorio Biagio
UOC Nefrologia, Ospedale Moscati, Avellino, Italia.
Cattedra di Nefrologia, Università Alma Mater Studiorum - Policlinico Sant'Orsola Bologna, Italia.
G Ital Nefrol. 2018 May;35(3).
Spontaneous urea dissociation in water solution is a prominent source of protein carbamylation in our body. Protein carbamylation is a well-known phenomenon since early seventies. Some years ago, much interest in the diagnostic power of carbamylated protein arouse. Recently the target of the researches focused on its potential cardiovascular pathogenicity. Some authors claimed that this could be a reason for higher cardiovascular mortality in uremic patients. Nutritional therapy, amino acids supplementation and intensive dialysis regimen are some of the therapeutic tools tested to lower the carbamylation burst in this population.
水溶液中尿素的自发解离是人体蛋白质氨甲酰化的一个重要来源。自20世纪70年代初以来，蛋白质氨甲酰化就是一个众所周知的现象。几年前，人们对氨甲酰化蛋白质的诊断价值产生了浓厚兴趣。最近，研究的重点集中在其潜在的心血管致病性上。一些作者声称，这可能是尿毒症患者心血管死亡率较高的一个原因。营养疗法、补充氨基酸和强化透析方案是为降低该人群氨甲酰化激增而测试的一些治疗手段。
