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在接受肺动脉瓣置换术的法洛四联症患者中额外进行三尖瓣环成形术的影响。

Impact of additional tricuspid valve annuloplasty in TOF patients undergoing pulmonary valve replacement.

作者信息

Lueck Sabrina, Bormann Eike, Rellensmann Kathrin, Martens Sven, Rukosujew Andreas

机构信息

Department of Cardiothoracic Surgery, Muenster University Hospital, Muenster, Germany -

Institute of Biostatistics and Clinical Research, Muenster University Hospital, Muenster, Germany.

出版信息

J Cardiovasc Surg (Torino). 2019 Apr;60(2):268-273. doi: 10.23736/S0021-9509.18.10385-5. Epub 2018 May 22.

Abstract

BACKGROUND

Many patients with tetralogy of Fallot (TOF) who underwent surgical correction of their congenital cardiac malformation during infancy develop right ventricular dysfunction and exercise intolerance in the long term. The right ventricle (RV) dilates due to the development of severe pulmonary regurgitation (and secondary tricuspid insufficiency). To reduce RV dilation and improve exercise tolerance pulmonary valve replacement (PVR) is the common therapeutic strategy. Whether concomitant tricuspid valve repair (TVR) is beneficial in these pure volume-overload conditions is still unknown.

METHODS

Twenty-eight adults who received surgical PVR were included in the study and perioperative data including operative records, postoperative course and echocardiography before and after surgery was analyzed retrospectively.

RESULTS

Mean age of the patients was 41.1±13.5 years and PVR with Carpentier Edwards Perimount bioprostheses was performed 32.0±9.5 years after initial cardiac surgery. Preoperative echocardiography revealed moderate RV dilation in 60.7% of the patients and severe pulmonary valve regurgitation in 82.3%. Ten patients underwent additional TVR. Indication was purely based on annular dilation (>40 mm), independent from the degree of tricuspid insufficiency. Periprocedural data of both groups did not differ significantly. However, ICU stay was significantly increased in patients who underwent additional TVR (P=0.0420) and these patients developed more complications (P=0.0407) while postoperative echography showed the same recovery of the RV function and diameters, independent of concomitant TVR.

CONCLUSIONS

In grown-ups with congenital heart disease surgical PVR with or without TVR is a safe procedure with good short-term outcomes. As the RV remodels after volume reduction, indication for concomitant TVR should be restrictive.

摘要

背景

许多在婴儿期接受先天性心脏畸形手术矫正的法洛四联症(TOF)患者,长期会出现右心室功能障碍和运动不耐受。由于严重肺动脉反流(以及继发性三尖瓣关闭不全)的发展,右心室(RV)会扩张。为了减少RV扩张并提高运动耐量,肺动脉瓣置换术(PVR)是常见的治疗策略。在这些单纯容量超负荷情况下,同期进行三尖瓣修复(TVR)是否有益仍不清楚。

方法

本研究纳入了28例接受外科PVR的成人患者,并对围手术期数据进行回顾性分析,包括手术记录、术后病程以及手术前后的超声心动图检查结果。

结果

患者的平均年龄为41.1±13.5岁,在初次心脏手术后32.0±9.5年进行了Carpentier Edwards Perimount生物瓣膜的PVR。术前超声心动图显示,60.7%的患者存在中度RV扩张,82.3%的患者存在严重肺动脉瓣反流。10例患者接受了额外的TVR。手术指征完全基于瓣环扩张(>40mm),与三尖瓣关闭不全的程度无关。两组的围手术期数据无显著差异。然而,接受额外TVR的患者重症监护病房(ICU)住院时间显著延长(P=0.0420),且这些患者出现更多并发症(P=0.0407),而术后超声心动图显示RV功能和直径的恢复情况相同,与是否同期进行TVR无关。

结论

对于先天性心脏病成人患者,无论是否进行TVR,外科PVR都是一种安全的手术,短期效果良好。由于容量减少后RV会发生重塑,同期进行TVR的指征应严格限制。

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