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本文引用的文献

1
Eligibility for Endovascular Trial Enrollment in the 6- to 24-Hour Time Window: Analysis of a Single Comprehensive Stroke Center.6 至 24 小时时间窗内血管内试验入组的资格:单一大卒中中心分析。
Stroke. 2018 Apr;49(4):1015-1017. doi: 10.1161/STROKEAHA.117.020273. Epub 2018 Mar 16.
2
Hip Fracture, Comorbidity, and the Risk of Myocardial Infarction and Stroke: A Danish Nationwide Cohort Study, 1995-2015.髋部骨折、合并症与心肌梗死和卒中风险:1995-2015 年丹麦全国队列研究
J Bone Miner Res. 2017 Dec;32(12):2339-2346. doi: 10.1002/jbmr.3242. Epub 2017 Sep 22.
3
Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice.小胶质细胞介导了小鼠术后海马炎症和认知能力下降。
JCI Insight. 2017 Apr 6;2(7):e91229. doi: 10.1172/jci.insight.91229.
4
Strategies to Extend Thrombolytic Time Window for Ischemic Stroke Treatment: An Unmet Clinical Need.延长缺血性脑卒中治疗溶栓时间窗的策略:一项未满足的临床需求。
J Stroke. 2017 Jan;19(1):50-60. doi: 10.5853/jos.2016.01515. Epub 2017 Jan 31.
5
Cognitive Differences between Men and Women who Fracture their Hip and Impact on Six-Month Survival.髋部骨折的男性和女性之间的认知差异及其对六个月生存率的影响。
J Am Geriatr Soc. 2017 Mar;65(3):e64-e69. doi: 10.1111/jgs.14674. Epub 2017 Feb 8.
6
Osteoporosis: fracture epidemiology update 2016.骨质疏松症:2016 年骨折流行病学更新。
Curr Opin Rheumatol. 2017 Mar;29(2):150-156. doi: 10.1097/BOR.0000000000000365.
7
Activation of Alpha-7 Nicotinic Acetylcholine Receptor Reduces Brain Edema in Mice with Ischemic Stroke and Bone Fracture.α7 型烟碱型乙酰胆碱受体激活减轻缺血性脑卒中合并骨折小鼠脑水肿
Mol Neurobiol. 2017 Dec;54(10):8278-8286. doi: 10.1007/s12035-016-0310-8. Epub 2016 Dec 2.
8
Risk of fractures after stroke: Results from the Ontario Stroke Registry.中风后骨折的风险:安大略中风登记处的结果。
Neurology. 2017 Jan 3;88(1):57-64. doi: 10.1212/WNL.0000000000003457. Epub 2016 Nov 23.
9
Parecoxib prevents early postoperative cognitive dysfunction in elderly patients undergoing total knee arthroplasty: A double-blind, randomized clinical consort study.帕瑞昔布预防老年全膝关节置换术患者术后早期认知功能障碍:一项双盲、随机临床联合研究。
Medicine (Baltimore). 2016 Jul;95(28):e4082. doi: 10.1097/MD.0000000000004082.
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Inflammatory Disequilibrium in Stroke.中风中的炎症失衡
Circ Res. 2016 Jun 24;119(1):142-58. doi: 10.1161/CIRCRESAHA.116.308022.

骨骨折对缺血性中风恢复的影响。

Impact of Bone Fracture on Ischemic Stroke Recovery.

机构信息

Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA.

出版信息

Int J Mol Sci. 2018 May 22;19(5):1533. doi: 10.3390/ijms19051533.

DOI:10.3390/ijms19051533
PMID:29786644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5983742/
Abstract

Stroke is one of the most devastating complications of bone fracture, occurring in up to 4% of patients after surgical repair for hip fracture. Bone fracture and ischemic stroke have many common risk factors. The impact of bone fracture on stroke recovery has not drawn much attention in the research field. Bone fracture could occur in stroke patients at different times during the recovery phase, which steepens the trajectory of cognitive decline, greatly affects the quality of life, and causes a heavy burden on healthcare resources. In this paper, we reviewed the growing information on the pathophysiological mechanisms by which bone fracture may affect ischemic stroke recovery process.

摘要

中风是骨折最严重的并发症之一,在接受髋关节骨折手术后,多达 4%的患者会出现这种并发症。骨折和缺血性中风有许多共同的危险因素。骨折对中风恢复的影响在研究领域并没有引起太多关注。中风患者在恢复阶段的不同时间可能会发生骨折,这会使认知能力下降的轨迹更加陡峭,极大地影响生活质量,并给医疗资源带来沉重负担。本文综述了越来越多的信息,这些信息涉及骨折可能影响缺血性中风恢复过程的病理生理机制。