血糖控制对链脲佐菌素诱导糖尿病大鼠肾小球滤过率的影响。

Effect of glycaemic control on glomerular filtration rate in the streptozotocin diabetic rat.

Jackson B, Franze L, Allen T J, O'Brien R, Cooper M, Hodsman G P, Jerums G

University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1988 Apr;15(4):361-5. doi: 10.1111/j.1440-1681.1988.tb01088.x.

Abstract

Diabetes was induced in 32 adult Wistar-Kyoto rats with streptozotocin (60 mg/kg). Fourteen rats remained untreated, 10 received insulin three times per week, and eight received insulin daily. Fourteen non-diabetic rats served as controls. 2. Exchangeable sodium and plasma volume were elevated in the untreated diabetic rats. Treatment normalized these parameters. 3. Glomerular filtration rate (GFR) was elevated in the untreated diabetic group and the group receiving insulin three times per week compared with the control group. Daily insulin treatment restored GFR towards control values. 4. Plasma atrial natriuretic factor was similar in untreated diabetic rats and non-diabetic rats.

摘要

用链脲佐菌素（60毫克/千克）诱导32只成年Wistar - Kyoto大鼠患糖尿病。14只大鼠未接受治疗，10只大鼠每周接受三次胰岛素治疗，8只大鼠每日接受胰岛素治疗。14只非糖尿病大鼠作为对照。2. 未治疗的糖尿病大鼠体内可交换钠和血浆容量升高。治疗使这些参数恢复正常。3. 与对照组相比，未治疗的糖尿病组和每周接受三次胰岛素治疗的组肾小球滤过率（GFR）升高。每日胰岛素治疗使GFR恢复到对照值。4. 未治疗的糖尿病大鼠和非糖尿病大鼠的血浆心钠素相似。