Department of Anesthesiology, Xiang Ya Hospital, Central South University, China.
Department of Anesthesiology, Xiang Ya Hospital, Central South University, China.
Int J Surg. 2018 Jul;55:73-80. doi: 10.1016/j.ijsu.2018.05.022. Epub 2018 May 19.
Numerous reports have indicated that preoperative Neutrophil-Lymphocyte ratio (NLR) was correlated with the prognosis of hepatocellular carcinoma who underwent hepatectomy. However, the results still remained controversial. Therefore, the present meta-analysis of 17 studies was performed to evaluate the prognostic value of preoperative NLR in HCC patients.
Databases of PubMed, Embase, Cochrane Library and Web of Science were retrieved. Hazard Ratio (HR) or Odds Ratio (OR) with its 95% confidence intervals (CI) was used to evaluate the association between preoperative NLR and the prognosis or clinical features of HCC patients.
A total of 17 studies eventually were included in this meta-analysis. Elevated preoperative NLR had a close relationship with the overall survival (OS) (HR 1.52; 95% CI 1.37-1.69), recurrence-free survival (RFS) (HR 1.64; 95% CI 1.44-1.87) and disease-free survival (DFS) (HR 1.50; 95% CI 1.35-1.67) of hepatocellular carcinoma. Additionally, preoperative NLR was also associated with tumor vascular invasion (OR 2.08; 95% CI 1.60-2.70), HBV (OR 0.68; 95% CI 0.51-0.90) and large tumor size (OR: 4.07; 95% CI 2.60-6.37).
The present meta-analysis indicated that preoperative NLR had significant association with the prognosis of hepatocellular carcinoma patients and may be an effectively prognostic indicator.
大量报告表明，术前中性粒细胞与淋巴细胞比值（NLR）与接受肝切除术的肝细胞癌患者的预后相关。然而，结果仍然存在争议。因此，本荟萃分析纳入了 17 项研究，旨在评估术前 NLR 对 HCC 患者预后的预测价值。
检索了 PubMed、Embase、Cochrane 图书馆和 Web of Science 数据库。采用风险比（HR）或优势比（OR）及其 95%置信区间（CI）评估术前 NLR 与 HCC 患者预后或临床特征之间的关系。
共有 17 项研究最终纳入本荟萃分析。术前 NLR 升高与总生存期（OS）（HR 1.52；95%CI 1.37-1.69）、无复发生存期（RFS）（HR 1.64；95%CI 1.44-1.87）和无病生存期（DFS）（HR 1.50；95%CI 1.35-1.67）密切相关。此外，术前 NLR 还与肿瘤血管侵犯（OR 2.08；95%CI 1.60-2.70）、HBV（OR 0.68；95%CI 0.51-0.90）和大肿瘤大小（OR：4.07；95%CI 2.60-6.37）相关。
本荟萃分析表明，术前 NLR 与肝细胞癌患者的预后有显著关联，可能是一种有效的预后指标。
