Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Eur Arch Psychiatry Clin Neurosci. 2019 Sep;269(6):645-655. doi: 10.1007/s00406-018-0902-6. Epub 2018 May 22.
We designed a study to investigate the patterns of the steady-state visual evoked potential (SSVEP) and auditory steady-state response (ASSR) in adolescents with attention-deficit/hyperactivity disorder (ADHD) when performing a motor response inhibition task. Thirty 12- to 18-year-old adolescents with ADHD and 30 healthy control adolescents underwent an electroencephalogram (EEG) examination during steady-state stimuli when performing a stop-signal task. Then, we calculated the amplitude and phase of the steady-state responses in both visual and auditory modalities. Results showed that adolescents with ADHD had a significantly poorer performance in the stop-signal task during both visual and auditory stimuli. The SSVEP amplitude of the ADHD group was larger than that of the healthy control group in most regions of the brain, whereas the ASSR amplitude of the ADHD group was smaller than that of the healthy control group in some brain regions (e.g., right hemisphere). In conclusion, poorer task performance (especially inattention) and neurophysiological results in ADHD demonstrate a possible impairment in the interconnection of the association cortices in the parietal and temporal lobes and the prefrontal cortex. Also, the motor control problems in ADHD may arise from neural deficits in the frontoparietal and occipitoparietal systems and other brain structures such as cerebellum.
我们设计了一项研究，旨在调查注意缺陷多动障碍（ADHD）青少年在执行运动反应抑制任务时，稳态视觉诱发电位（SSVEP）和稳态听觉反应（ASSR）的模式。30 名 12 至 18 岁的 ADHD 青少年和 30 名健康对照青少年在执行停止信号任务时接受了稳态刺激的脑电图（EEG）检查。然后，我们计算了视觉和听觉两种模态下稳态反应的振幅和相位。结果表明，ADHD 青少年在视觉和听觉刺激下的停止信号任务表现明显较差。与健康对照组相比，ADHD 组的 SSVEP 振幅在大脑的大多数区域都较大，而 ADHD 组的 ASSR 振幅在一些大脑区域（例如右半球）则较小。总之，ADHD 患者较差的任务表现（尤其是注意力不集中）和神经生理学结果表明，顶叶和颞叶以及前额叶的联合皮质之间的连接可能受损。此外，ADHD 的运动控制问题可能源于额顶叶和枕顶叶系统以及小脑等其他脑结构的神经缺陷。
