Cho S B, Park J, Zheng Z, Yoo K H, Kim H
Department of Dermatology and Cutaneous Biology Research Center, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea.
Kangskin Dermatology Clinic, Seoul, Korea.
Skin Res Technol. 2019 Jan;25(1):30-39. doi: 10.1111/srt.12591. Epub 2018 May 23.
Energy-delivering devices can be used to induce thermal coagulation of the eccrine sweat glands for treating primary axillary hyperhidrosis (PAH).
The objective of this study was to compare the efficacy and safety of invasive, bipolar radiofrequency (RF) treatment for PAH.
A split-axilla study was performed to compare the clinical outcomes of 0.5 MHz, invasive, bipolar RF treatment with treatment settings of a longer conduction time and lower power (LC/LP) vs a shorter conduction time and higher power (SC/HP) for treating PAH.
The in vivo study revealed median hyperhidrosis disease severity scale scores of 1.5 (interquartile range [IQR], 1-2) at 1 month and 1 (IQR, 1-2) at 3 months after treatment with the LC/LP setting, compared to baseline. Meanwhile, the other side of the axillae treated with the SC/HP setting showed scores of 2 (IQR, 2-2) at 1 month and 2 (IQR, 1.25-2) at 3 months. Analysis via a linear mixed model revealed a significant interaction (group, P = .011; time, P < .001; and group × time, P = .048) between treatment group and time.
PAH can be effectively and safely treated with invasive, multilayered, multiple-pass, 0.5-MHz, bipolar RF treatment, particularly with LC/LP.
能量传递设备可用于诱导小汗腺热凝，以治疗原发性腋窝多汗症（PAH）。
本研究的目的是比较侵入性双极射频（RF）治疗PAH的疗效和安全性。
进行了一项双侧腋窝对照研究，比较0.5MHz侵入性双极RF治疗在较长传导时间和较低功率（LC/LP）与较短传导时间和较高功率（SC/HP）的治疗设置下治疗PAH的临床结果。
体内研究显示，与基线相比，采用LC/LP设置治疗后1个月多汗症疾病严重程度量表中位数评分为1.5（四分位间距[IQR]，1 - 2），3个月时为1（IQR，1 - 2）。同时，采用SC/HP设置治疗的另一侧腋窝在1个月时评分为2（IQR，2 - 2），3个月时为2（IQR，1.25 - 2）。通过线性混合模型分析显示，治疗组和时间之间存在显著交互作用（组，P = 0.011；时间，P < 0.001；组×时间，P = 0.048）。
侵入性、多层、多通道、0.5MHz双极RF治疗可有效且安全地治疗PAH，尤其是采用LC/LP设置时。
