酒精暴露对谷氨酸能系统的影响：一项在大鼠中进行的联合纵向 F-FPEB 和 H-MRS 研究。
Effects of alcohol exposure on the glutamatergic system: a combined longitudinal F-FPEB and H-MRS study in rats.
机构信息
KU Leuven - University of Leuven, MoSAIC, Molecular Small Animal Imaging Center, Belgium.
KU Leuven - University of Leuven/University Hospital Leuven, Division of Nuclear Medicine, Department of Imaging and Pathology, Belgium.
出版信息
Addict Biol. 2019 Jul;24(4):696-706. doi: 10.1111/adb.12635. Epub 2018 May 23.
In a longitudinal rat model of alcohol consumption, we showed that exposure to alcohol decreased the concentration of glutamate in the prefrontal cortex, whereas a normalization occurred during abstinence. 18F-FPEB PET scans revealed that pre-exposure mGluR5 availability in the nucleus accumbens was associated with future alcohol preference. Finally, alcohol exposure induced a decrease in mGluR5 availability in the bilateral hippocampus and amygdala compared with baseline, and in the hippocampus and striatum compared with saccharin (Figure).
在一个酒精摄入的纵向大鼠模型中，我们发现，暴露于酒精会降低前额叶皮层中谷氨酸的浓度，而在戒断期间则会恢复正常。18F-FPEB PET 扫描显示，伏隔核内 mGluR5 的预先暴露可用性与未来的酒精偏好有关。最后，与基线相比，酒精暴露导致双侧海马体和杏仁核中 mGluR5 的可用性下降，与蔗糖相比，在海马体和纹状体中也出现了下降（图）。
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